Panniculitis
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References
Erythema nodosum is the most common form of panniculitis and is characterized by tender erythematous nodules mainly in the lower limbs on the pretibial area. The exact cause of erythema nodosum is unknown, although it appears to be a hypersensitivity response to a variety of antigenic stimuli. Although the etiology is mostly idiopathic, ruling out an underlying disease is imperative before diagnosing primary erythema nodosum. Erythema nodosum can be the first sign of a systemic disease that is triggered by a large group of processes, such as infections, inflammatory diseases, neoplasia, and/or drugs. The most common identifiable causes are streptococcal infections, primary tuberculosis, sarcoidosis, Behçet disease, inflammatory bowel disease, drugs, and pregnancy.
Panniculitis cruthaich buidheann heterogenous de ghalaran inflammatory a tha a’ toirt a-steach clò adipose subcutaneous. Tha na duilgheadasan sin gu math tearc ann an cloinn. Faodaidh am panniculitis a bhith na phrìomh phròiseas ann an eas-òrdugh siostamach no pròiseas àrd-sgoile a thig bho ghalar, trauma no nochdadh do chungaidh-leigheis. Tha an aon taisbeanadh clionaigeach aig a ‘mhòr-chuid de sheòrsaichean panniculitis (ge bith dè an eòlas-eòlas) , le nodules tairgse, erythematous subcutaneous.
Panniculitides form a heterogenous group of inflammatory diseases that involve the subcutaneous adipose tissue. These disorders are rare in children and have many aetiologies. As in adults, the panniculitis can be the primary process in a systemic disorder or a secondary process that results from infection, trauma or exposure to medication. Some types of panniculitis are seen more commonly or exclusively in children, and several new entities have been described in recent years. Most types of panniculitis have the same clinical presentation (regardless of the aetiology), with tender, erythematous subcutaneous nodules.
Panniculitides form a heterogenous group of inflammatory diseases that involve the subcutaneous adipose tissue. These disorders are rare in children and have many aetiologies. As in adults, the panniculitis can be the primary process in a systemic disorder or a secondary process that results from infection, trauma or exposure to medication. Some types of panniculitis are seen more commonly or exclusively in children, and several new entities have been described in recent years. Most types of panniculitis have the same clinical presentation (regardless of the aetiology), with tender, erythematous subcutaneous nodules.
Panniculitis , sèid an geir subcutaneous, mar as trice a’ nochdadh le nodules inflammatory. Is e Erythema nodosum (EN) gu clinigeach an seòrsa panniculitis as cumanta. Ged a tha suas ri 55% de EN air a mheas idiopathic, tha na h-adhbharan as cumanta a’ toirt a-steach galairean, drogaichean, tinneasan siostamach leithid sarcoidosis agus galair innidh inflammatory, torrachas, agus malignancy. Mar as trice bidh EN a’ nochdadh anns na deugairean agus 20n, agus mar as trice ri fhaicinn ann am boireannaich. Gu tric bidh prodrome neo-shònraichte de aon no trì seachdainean roimhe, a dh’ fhaodadh a bhith a’ toirt a-steach fiabhras, malaise, agus comharran galair analach àrd. Bidh leòintean cutaneous an uairsin a’ leantainn, mar as trice air an suidheachadh gu h-ionadail air taobh a-muigh nan buill-bodhaig. Tha na h-eucoirean pianail cruinn no ugh-chruthach, nodulan dearg beagan àrdaichte, neo-ulcerative. Chan eilear a’ tuigsinn an dearbh pathogenesis de EN, ged a thathas den bheachd gu bheil e mar thoradh air a bhith a’ tasgadh toinntean dìon ann am venules nan septae ann an geir subcutaneous, ag adhbhrachadh panniculitis neutrophilic. Fiù ‘s às aonais leigheas sònraichte airson suidheachadh adhbharach, bidh EN a’ fuasgladh gun làimhseachadh sa mhòr-chuid de chùisean.
Panniculitis, inflammation of the subcutaneous fat, usually presents with inflammatory nodules. Erythema nodosum (EN) is clinically the most frequent form of panniculitis. Whilst up to 55% of EN is considered idiopathic, the most common causes include infections, drugs, systemic illnesses such as sarcoidosis and inflammatory bowel disease, pregnancy, and malignancy. EN typically presents in the teens and 20s, and is seen more commonly in females. It is often preceded by a non-specific prodrome of one to three weeks, which may include fever, malaise, and symptoms of an upper respiratory tract infection. Cutaneous lesions then follow, typically localized on the extensor aspect of the limbs. The lesions are painful rounded or oval, slightly raised, non-ulcerative red nodules. The exact pathogenesis of EN is not understood, although is thought to result from deposition of immune complexes in the venules of the septae in subcutaneous fat, causing a neutrophilic panniculitis. Even without specific therapy for a causative condition, EN resolves without treatment in most cases.
Panniculitis, inflammation of the subcutaneous fat, usually presents with inflammatory nodules. Erythema nodosum (EN) is clinically the most frequent form of panniculitis. Whilst up to 55% of EN is considered idiopathic, the most common causes include infections, drugs, systemic illnesses such as sarcoidosis and inflammatory bowel disease, pregnancy, and malignancy. EN typically presents in the teens and 20s, and is seen more commonly in females. It is often preceded by a non-specific prodrome of one to three weeks, which may include fever, malaise, and symptoms of an upper respiratory tract infection. Cutaneous lesions then follow, typically localized on the extensor aspect of the limbs. The lesions are painful rounded or oval, slightly raised, non-ulcerative red nodules. The exact pathogenesis of EN is not understood, although is thought to result from deposition of immune complexes in the venules of the septae in subcutaneous fat, causing a neutrophilic panniculitis. Even without specific therapy for a causative condition, EN resolves without treatment in most cases.
Tha “Erythema nodosum” na sheòrsa de panniculitis air a chomharrachadh le nodules dearga tairgse, 1-10 cm, co-cheangailte ri comharran siostamach a’ toirt a-steach fiabhras, malaise, agus pian co-phàirteach. Faodaidh nodulan a dhol sìos thar ùine de 2-6 seachdainean gun a bhith a 'faighinn ulcer no sgrìobadh. Tha erythema nodosum co-cheangailte ri galairean, a’ toirt a-steach Hepatitis C, EBV agus caitheamh, torrachas, lymphoma neo-Hodgkin, agus aillse pancreatic.