Porokeratosis
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Tha na h-oirean cruaidh protruding àbhaisteach.
References
Is e suidheachadh craiceann tearc a th’ ann an Porokeratosis a tha air a chomharrachadh le duilgheadasan keratinization, a’ leantainn gu pìosan àrdaichte, cumadh fàinne no cnapan garbh air a’ chraiceann. Is e am feart sònraichte aige fon mhiocroscop làthaireachd cornoid lamella, rèiteachadh sònraichte de cheallan ann an ìre àrd a’ chraicinn. Tha Porokeratosis a’ tighinn ann an diofar chruthan (disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, linear porokeratosis) . Tha e cudromach cuimhneachadh gum faodadh porokeratosis fàs gu bhith na aillse craicinn. Is e an dòigh as fheàrr air porokeratosis a dhearbhadh tro biopsy den chrìch àrdaichte, ged nach eil protocol làimhseachaidh àbhaisteach ann an-dràsta.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Tha Disseminated superficial actinic porokeratosis (DSAP) na ghalar de keratinization mì-rianail. Is e seo aon de shia seòrsaichean porokeratosis, agus mar as trice bidh e a’ toirt buaidh air raointean nas motha an taca ris an fheadhainn eile (linear, Mibelli's, punctate, palmoplantar disseminated, superficial porokeratosis) . Bidh an seòrsa spùtach de porokeratosis gu tric a’ ceangal ri aillse, dìonachd lag, no sèid. Tha factaran cunnart a’ toirt a-steach gintinneachd, casg dìonachd, agus foillseachadh grèine. Bidh DSAP a’ tòiseachadh mar chnapan pinc no donn le oirean àrdaichte ann an ceàrnaidhean le solas grèine, uaireannan ag adhbhrachadh beagan tachais. Bidh làimhseachadh ag atharrachadh agus faodaidh iad a bhith a’ toirt a-steach uachdaran gnàthach, leigheas aotrom, no cungaidhean mar 5-fluorouracil no retinoids. Thathas den bheachd gu bheil na leòintean sin ro aillse, le cothrom 7. 5 - 10 % tionndadh gu carcinoma cealla squamous no cealla basal.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Thàinig fireannach 52-bliadhna, a bha fallain roimhe seo, a-steach le bad còmhnard ann an cumadh fàinne air deireadh a cheathramh ladhar, a bha air a bhith ann airson 2 bhliadhna gun chomharran sam bith adhbhrachadh. Thòisich e mar chnap beag, cruaidh agus dh’ fhàs e a-muigh thar ùine. A dh 'aindeoin a bhith a' feuchainn diofar leigheasan leithid cryotherapy, uachdaran, antifungals, agus antibiotics, cha do dh'fhàs am paiste nas fheàrr. Le bhith ga sgrùdadh gu dlùth le dermocopsy sheall e ionad tioram, dearg le crìoch tiugh, garbh. Sheall pìos beag craiceann a chaidh a thoirt bho oir a’ phaiste fàs cealla neo-àbhaisteach ann an còmhdach a-muigh a’ chraicinn, a’ dearbhadh gun deach porokeratosis of Mibelli a dhearbhadh.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
Gu tric bidh biopsy air a dhèanamh oir faodaidh e coimhead coltach ri keratosis actinic no carcinoma cealla squamous.