Keratoacanthoma - Queratoacantoma
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Típico Queratoacantoma (Keratoacanthoma)
References
Keratoacanthoma (KA) é un tumor de pel frecuente coñecido polo seu rápido crecemento e potencial para regresar por si só. Adoita ocorrer en homes maiores e de pel clara con antecedentes de danos solares. Aínda que a extirpación cirúrxica mediante escisión ou cirurxía micrográfica de Mohs é o tratamento habitual, hai outras opcións de terapia dispoñibles.
Keratoacanthoma (KA) is a common cutaneous tumor characterized by rapid growth and possible spontaneous regression. It most commonly affects older, fair-skinned males with significantly sun damaged skin. Although surgical removal with excision or Mohs micrographic surgery remains the standard of therapy, there are many alternative therapeutic modalities that can be utilized.
Keratoacanthoma (KA) is a common cutaneous tumor characterized by rapid growth and possible spontaneous regression. It most commonly affects older, fair-skinned males with significantly sun damaged skin. Although surgical removal with excision or Mohs micrographic surgery remains the standard of therapy, there are many alternative therapeutic modalities that can be utilized.
Keratoacanthoma (KA) é un tumor de baixo grao que comeza en certas glándulas da pel e se parece ao squamous cell carcinoma (SCC) baixo un microscopio. Hai un debate en curso sobre se o KA debería clasificarse como unha forma de SCC invasivo.
Keratoacanthoma (KA) is a comparatively common low-grade tumor that initiates in the pilo-sebaceous glands and pathologically mimics squamous cell carcinoma (SCC). Essentially, strong debates confirm classifying keratoacanthoma as a variant of invasive SCC. The clinical behavior of KA is hardly predictable and the differential diagnosis of keratoacanthoma and other conditions with keratoacanthoma-like pseudocarcinomatous epithelial hyperplasia is challenging, both clinically and histopathologically.
Keratoacanthoma (KA) is a comparatively common low-grade tumor that initiates in the pilo-sebaceous glands and pathologically mimics squamous cell carcinoma (SCC). Essentially, strong debates confirm classifying keratoacanthoma as a variant of invasive SCC. The clinical behavior of KA is hardly predictable and the differential diagnosis of keratoacanthoma and other conditions with keratoacanthoma-like pseudocarcinomatous epithelial hyperplasia is challenging, both clinically and histopathologically.
Cutaneous squamous cell carcinoma (cSCC) é o segundo tipo de cancro máis común nas persoas, especialmente entre as persoas maiores. A cirurxía adoita usarse para tratar cSCC, pero para algúns pacientes que non poden operarse ou optan por non facelo, pódense considerar outras opcións como tratamentos intralesionales. Utilizáronse tratamentos intralesionales tradicionais (methotrexate or 5-fluorouracil) , pero hai investigacións en curso sobre novos enfoques como a inmunoterapia intralesional e a viroterapia oncolítica. Aquí, analizaremos diferentes tratamentos intralesionales para cSCC, que van desde métodos clásicos ata estratexias de vangarda.
Cutaneous squamous cell carcinoma (cSCC) is the second most frequent cancer in humans, and it is especially common in fragile, elderly people. Surgery is the standard treatment for cSCC but intralesional treatments can be an alternative in those patients who are either not candidates or refuse to undergo surgery. Classic intralesional treatments, including methotrexate or 5-fluorouracil, have been implemented, but there is now a landscape of active research to incorporate intralesional immunotherapy and oncolytic virotherapy into the scene, which might change the way we deal with cSCC in the future. In this review, we focus on intralesional treatments for cSCC (including keratoacanthoma), from classic to very novel strategies.
Cutaneous squamous cell carcinoma (cSCC) is the second most frequent cancer in humans, and it is especially common in fragile, elderly people. Surgery is the standard treatment for cSCC but intralesional treatments can be an alternative in those patients who are either not candidates or refuse to undergo surgery. Classic intralesional treatments, including methotrexate or 5-fluorouracil, have been implemented, but there is now a landscape of active research to incorporate intralesional immunotherapy and oncolytic virotherapy into the scene, which might change the way we deal with cSCC in the future. In this review, we focus on intralesional treatments for cSCC (including keratoacanthoma), from classic to very novel strategies.
Ao microscopio, queratoacantoma (keratoacanthoma) parécese moito ao carcinoma de células escamosas. Aínda que algúns patólogos clasifican o queratoacantoma (keratoacanthoma) como unha entidade distinta e non como un tumor maligno, preto do 6% dos queratoacantoma (keratoacanthoma) clínicos e histolóxicos progresan a cancros de células escamosas invasivas e agresivas.
○ Diagnóstico e Tratamento
#Dermoscopy
#Skin biopsy