Prurigo nodularis
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ReferencesPrurigo nodularis é unha afección cutánea de longa duración, caracterizada por múltiples protuberancias e nódulos firmes que adoitan atoparse nas áreas externas dos brazos e das pernas. Estas lesións poden variar de cor desde o ton da carne ata o rosa e son moi pruriginosas. Pode afectar a persoas de calquera idade e, con frecuencia, está asociada a outras enfermidades cutáneas que provocan comezón crónica, como a dermatite atópica. As opcións de tratamento inclúen fármacos potentes anti‑pruriginosos, inmunomoduladores e medicamentos que actúan sobre o sistema nervioso. O tratamento do prurigo nodular normalmente implica terapia a longo prazo.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
O tratamento xeralmente implica o uso de cremas ou inxeccións de esteroides na zona afectada. En casos máis graves ou teimudos, poden ser necesarios tratamentos como terapia de luz ou medicamentos que suprimen o sistema inmunitario. A talidomida e a lenalidomida son opcións para casos graves, pero poden provocar efectos secundarios graves. Os tratamentos máis novos (opioid receptor antagonists, neurokinin-1 receptor antagonists) son prometedores no tratamento do prurigo nodular, con menos efectos secundarios en comparación coa talidomida ou a lenalidomida.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Chronic prurigo é unha afección da pel caracterizada por comezón de longa duración (máis de 6 semanas), lesións cutáneas relacionadas co rascado e antecedentes de rascado frecuente. A condición implica neuroinflamación e fibrose na pel.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Prurigo nodularis é un problema crónico da pel caracterizado por nódulos pruriginosos. Non sabemos exactamente a súa causa, pero parece que os trastornos inmunes e nervosos xogan un papel no ciclo da coceira e do rascado. Actualmente, non existe ningún tratamento aprobado pola FDA dos Estados Unidos especificamente para o prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
○ Tratamento - Medicamentos OTC
Lavar a zona da lesión con xabón non axuda en absoluto e pode empeoralo. Os ungüentos de esteroides OTC poden axudar a aliviar os síntomas, pero normalmente necesitan ser aplicados durante varias semanas para mellorar. Continuar tomando antihistamínicos tamén axuda a aliviar a coceira.
#OTC steroid ointment
#OTC antihistamine
○ Tratamento
#Intralesional triamcinolone injection