Acute generalized exanthematous pustulosis
Acute generalized exanthematous pustulosis (AGEP) wani nau'in halayen fata ne da ba kasafai ba wanda a cikin kashi 90% na lokuta yana da alaƙa da gudanar da magani. Acute generalized exanthematous pustulosis yana da alamun fashewar fata kwatsam wanda ke bayyana a matsakaicin kwanaki biyar bayan an fara magani. Wadannan fashe-fashe ne magudanar ruwa, watau kananan jajayen fari ko jajayen firar fata mai dauke da gajimare ko abu mai sheki (pus). Raunin fata yakan warware a cikin kwanaki 1-3 bayan dakatar da maganin da ya sabawa.
☆ A cikin sakamakon Stiftung Warentest na 2022 daga Jamus, gamsuwar mabukaci tare da ModelDerm ya ɗan yi ƙasa kaɗan fiye da biyan shawarwarin telemedicine.
Yaduwan raunuka tare da erythema da pustules suna bayyana ba zato ba tsammani.
References
Acute generalized exanthematous pustulosis (AGEP) shine maganin fata da aka yi masa alama da ƴan ƙanana, cike da kumburi a gindin fata mai ja. Yawancin lokaci yana faruwa lokacin da wani ya ɗauki wasu magunguna, kamar maganin rigakafi, kuma ya bazu cikin sauri a cikin jiki. Bayan dakatar da maganin da ke haifar da cutar, alamun yawanci suna tafiya a cikin makonni biyu, yawanci suna barin wasu zubar da fata. Ko da yake yawanci ba mai tsanani ba ne kuma yana iyakance ga fata, ana iya rarraba lokuta masu tsanani tare da sauran halayen fata kamar Stevens-Johnson syndrome ko toxic epidermal necrolysis. Jiyya shine kulawa na farko na tallafi, kuma tsinkaye don cikakken maganin cutar yawanci yana da kyau.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
Wani dattijo mai shekaru 76 ya zo dakin gaggawa saboda fatar jikinsa ta canza a cikin kwanaki biyu da suka gabata. Likitoci sun sami jajayen faci kuma sun ɗaga wurare a jikin sa da hannaye da ƙafafu. Yayin da lokaci ya ci gaba, waɗannan facin sun haɗu tare, kuma ya sami ƙumburi-kamar pimples a wuraren ja. Gwaje-gwaje sun nuna yawan adadin fararen jini mai yawa tare da nau'in nau'in neutrophils, da karuwar matakan C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
