Porokeratosishttps://en.wikipedia.org/wiki/Porokeratosis
Porokeratosis cuta ce ta keratinization da ba kasafai ba. Porokeratosis yana da alaƙa da raunukan fata waɗanda ke farawa a matsayin ƙanana, papules masu launin ruwan kasa waɗanda sannu a hankali suna haɓaka don samar da raunuka marasa daidaituwa, annular, hyperkeratotic ko wart-kamar raunuka.

Sau da yawa ana yin biopsy saboda yana iya kama da actinic keratosis ko squamous cell carcinoma.

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  • Ƙaƙƙarfan gefuna masu tasowa suna da halaye.
    References Porokeratosis 30335323 
    NIH
    Porokeratosis shine yanayin fata da ba kasafai ba wanda ke da matsalolin keratinization, wanda ke haifar da tashe, faci mai siffar zobe ko muguwar kumbura akan fata. Ma'anar fasalinsa a ƙarƙashin na'urar hangen nesa shine kasancewar cornoid lamella, takamaiman tsari na sel a saman saman fata. Porokeratosis yana zuwa ta hanyoyi daban-daban (disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, linear porokeratosis) . Yana da mahimmanci a lura cewa porokeratosis na iya yuwuwar haɓaka zuwa kansar fata. Hanya mafi kyau don gano cutar porokeratosis ita ce ta hanyar biopsy na kan iyakar da aka taso, kodayake a halin yanzu babu wata ƙa'idar magani.
    Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
     Disseminated Superficial Actinic Porokeratosis 29083728 
    NIH
    Disseminated superficial actinic porokeratosis (DSAP) cuta ce ta rashin lafiyar keratinization. Yana ɗaya daga cikin nau'ikan porokeratosis guda shida, kuma yawanci yana shafar manyan yankuna idan aka kwatanta da sauran (linear, Mibelli's, punctate, palmoplantar disseminated, superficial porokeratosis) . Nau'in porokeratosis mai fashewa yakan haɗu da ciwon daji, raunin rigakafi, ko kumburi. Abubuwan haɗari sun haɗa da kwayoyin halitta, danne garkuwar jiki, da bayyanar rana. DSAP yana farawa azaman ruwan hoda ko launin ruwan kasa tare da tashe gefuna a wuraren da rana ke fallasa, wani lokacin yana haifar da ƙaiƙayi kaɗan. Jiyya sun bambanta kuma suna iya haɗawa da kirim mai tsami, maganin haske, ko magunguna kamar 5-fluorouracil ko retinoids. Ana ɗaukar waɗannan raunuka a matsayin masu riga-kafi, tare da 7. 5 - 10 % damar rikiɗawa zuwa squamous cell ko basal cell carcinoma.
    Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
     Porokeratosis of Mibelli - Case reports 33150040 
    NIH
    Wani mutum mai shekaru 52, a baya koshin lafiya, ya shigo da wani lebur mai siffar zobe a karshen yatsansa na hudu, wanda ya shafe shekaru 2 a wurin ba tare da ya haifar da wata alama ba. Ya fara a matsayin ƙarami, mai wuya kuma ya girma a waje na tsawon lokaci. Duk da ƙoƙarin jiyya daban-daban kamar cryotherapy, creams, antifungals, da maganin rigakafi, facin bai sami kyau ba. Yin nazarinsa a hankali tare da dermocopsy ya nuna busasshiyar, jan cibiya mai kauri mai kauri. Wata ‘yar karamar fata da aka dauko daga gefen facin ta nuna rashin ci gaban kwayoyin halitta a saman fatar jikin, wanda ke tabbatar da kamuwa da cutar porokeratosis of Mibelli.
    A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.