עוד מידע ― עִברִית

Tranexamic acid is a novel treatment option for melasma; however, there is no consensus on its use. This systematic review searched major databases for relevant publications to March 2016. Eleven studies with 667 participants were included. Pooled data from tranexamic acid-only observational studies with pre- and post-treatment Melasma Area and Severity Index (MASI) showed a decrease of 1.60 in MASI after treat?ment with tranexamic acid. The addition of tranexamic acid to routine treatment modalities resulted in a further decrease in MASI of 0.94. These results support the efficacy and safety of tranexamic acid, either alone or as an adjuvant to routine treatment modalities for melasma.

לאחרונה, low-fluence Q-switched Nd:YAG (LFQSNY) לייזר הפך פופולרי לטיפול במלזמה, במיוחד באסיה. סיכום מחקרים מגוונים היה מאתגר, אך LFQSNY נראה בדרך כלל יעיל ובטוח למלזמה בהשוואה לטיפולים מסורתיים. עם זאת, כמה מקרים של היפופיגמנטציה מנומרת דווחו כתופעת לוואי של LFQSNY, אולי בשל אנרגיית לייזר גבוהה. שימוש אגרסיבי ב-LFQSNY יכול גם להוביל להיפרפיגמנטציה כתוצאה מדלקת, במיוחד בגווני עור כהים יותר.
Recently, the low-fluence Q-switched Nd:YAG laser (LFQSNY) has been widely used for treating melasma, especially in Asia. It was hard to summarize the heterogenous studies, but LFQSNY appeared to be a generally effective and safe treatment for melasma considering the results of previous conventional therapies. However, mottled hypopigmentation has been occasionally reported to develop and persist as an adverse event of LFQSNY, which may be associated with the high accumulated laser energy. When used aggressively, even LFQSNY can induce hyperpigmentation via unwanted inflammation, especially in darker skin.

בעיות פיגמנטציה נמצאות לרוב בטיפול ראשוני. סוגים נפוצים של הפרעות היפרפיגמנטציה כוללים post-inflammatory hyperpigmentation, melasma, sunspots, freckles, and café au lait spots.
Pigmentation problems are often found in primary care. Common types of hyperpigmentation disorders include post-inflammatory hyperpigmentation, melasma, sunspots, freckles, café au lait spots.