Intraepithelial carcinoma (Bowen disease) - Intraepitelni Karcinom (Bowenova Bolest)
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Tipičan slučaj ― Intraepitelni Karcinom (Bowenova Bolest) (Intraepithelial carcinoma (Bowen disease)) se može pogrešno dijagnosticirati kao dugotrajni ekcem bez svrbeža.
References
Bowen's disease (BD) je vrsta raka kože koja počinje u vanjskom sloju kože (epidermisu) . Češći je kod bijelaca i često se javlja u područjima izloženim sunčevoj svjetlosti, ali se može pojaviti i drugdje. BD se obično pojavljuje kao jedna lezija. BD se često smatra znakom upozorenja prije nego što se razvije ozbiljnija vrsta raka kože. Da bi dijagnosticirali BD, liječnici se obično oslanjaju na ispitivanje uzoraka tkiva pod mikroskopom (biopsija) .
Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the lull before the storm, which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis.
Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the lull before the storm, which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis.
Bowen's disease uglavnom pogađa bijelce starije od 60 godina. Ključni čimbenici rizika uključuju dugotrajnu izloženost suncu, oslabljen imunološki sustav, izloženost arsenu i HPV infekciju kože. HPV sojevi 16, 18, 34 i 48 povezani su s Bowenovom bolešću u genitalnom području. Uključenost HPV-a u negenitalne slučajeve manje je jasna.
Bowen disease is most commonly found in white patients over 60 years old. Other risk factors include chronic sun exposure, immunosuppression, arsenic exposure and cutaneous human papillomavirus (HPV) infection. HPV types 16, 18, 34 and 48 cause Bowen disease at genital sites; the role of HPV in nongenital cases of Bowen disease is less well defined. HPV types 2, 16, 34 and 35 have been rarely identified within nongenital lesions.
Bowen disease is most commonly found in white patients over 60 years old. Other risk factors include chronic sun exposure, immunosuppression, arsenic exposure and cutaneous human papillomavirus (HPV) infection. HPV types 16, 18, 34 and 48 cause Bowen disease at genital sites; the role of HPV in nongenital cases of Bowen disease is less well defined. HPV types 2, 16, 34 and 35 have been rarely identified within nongenital lesions.
Obično se pojavljuje kao eritematozno, ljuskavo ili krasto područje bilo gdje na tijelu. Najčešća lokalizacija su potkoljenice.
Izlječiva je različitim mogućnostima liječenja kao što su krioterapija, kiretaža, kauterizacija, fotodinamička terapija ili izrezivanje lezije.
○ Dijagnostika i liječenje
#Dermoscopy
#Skin biopsy
#Mohs surgery
#Photodynamic therapy