Lupus erythematosus
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Leptirasti osip koji se obično pojavljuje na licu.
References
Identificiranje i klasificiranje cutaneous lupus erythematosus (CLE) postavlja dijagnostičke izazove, razlikovanje od systemic lupus erythematosus sa zahvaćenom kožom. Nedavne studije bacaju svjetlo na genetske, okolišne i imunološke čimbenike koji leže u pozadini CLE-a. Posebno se indukcija lijeka pokazala kao jedan od najvažnijih okidača za CLE. Liječenje uključuje topikalne i sistemske terapije, uključujući obećavajuće biološke lijekove poput belimumab, rituximab, ustekinumab, anifrolumab, and BIIB059 , s dokazanom učinkovitošću u kliničkim ispitivanjima.
Diagnostic challenges exist in better defining cutaneous lupus erythematosus (CLE) as an independent disease distinct from systemic lupus erythematosus with cutaneous features and further classifying CLE based on clinical, histological, and laboratory features. Recent mechanistic studies revealed more genetic variations, environmental triggers, and immunologic dysfunctions that are associated with CLE. Drug induction specifically has emerged as one of the most important triggers for CLE. Treatment options include topical agents and systemic therapies, including newer biologics such as belimumab, rituximab, ustekinumab, anifrolumab, and BIIB059 that have shown good clinical efficacy in trials.
Diagnostic challenges exist in better defining cutaneous lupus erythematosus (CLE) as an independent disease distinct from systemic lupus erythematosus with cutaneous features and further classifying CLE based on clinical, histological, and laboratory features. Recent mechanistic studies revealed more genetic variations, environmental triggers, and immunologic dysfunctions that are associated with CLE. Drug induction specifically has emerged as one of the most important triggers for CLE. Treatment options include topical agents and systemic therapies, including newer biologics such as belimumab, rituximab, ustekinumab, anifrolumab, and BIIB059 that have shown good clinical efficacy in trials.
Cutaneous lupus erythematosus (CLE) pokriva različite probleme s kožom, od kojih se neki mogu povezati sa širim zdravstvenim problemima. Kategoriziran je u različite vrste, kao što je acute CLE (ACLE) , sub-acute CLE (SCLE) , and chronic CLE (CCLE) . CCLE sadrži discoid lupus erythematosus (DLE) , LE profundus (LEP) , chilblain cutaneous lupus, and lupus tumidus.
Cutaneous lupus erythematosus (CLE) encompasses a wide range of dermatologic manifestations, which may or may not be associated with the development of systemic disease. Cutaneous lupus is divided into several sub-types, including acute CLE (ACLE), sub-acute CLE (SCLE) and chronic CLE (CCLE). CCLE includes discoid lupus erythematosus (DLE), LE profundus (LEP), chilblain cutaneous lupus and lupus tumidus.
Cutaneous lupus erythematosus (CLE) encompasses a wide range of dermatologic manifestations, which may or may not be associated with the development of systemic disease. Cutaneous lupus is divided into several sub-types, including acute CLE (ACLE), sub-acute CLE (SCLE) and chronic CLE (CCLE). CCLE includes discoid lupus erythematosus (DLE), LE profundus (LEP), chilblain cutaneous lupus and lupus tumidus.
Lupus erythematosus je skupina autoimunih bolesti koje mogu zahvatiti različite dijelove tijela. Neke vrste, poput systemic lupus erythematosus (SLE) , utječu na više organa, dok druge, poput cutaneous lupus erythematosus (CLE) , uglavnom utječu na kožu. Različite tipove CLE-a kategoriziramo na temelju kombinacije kliničkih znakova, pregleda tkiva i krvnih pretraga, ali postoji mnogo varijacija među pojedincima. Problemi s kožom često se razvijaju zbog čimbenika poput izlaganja sunčevoj svjetlosti, pušenja ili određenih lijekova.
Lupus erythematosus comprises a spectrum of autoimmune diseases that may affect various organs (systemic lupus erythematosus [SLE]) or the skin only (cutaneous lupus erythematosus [CLE]). Typical combinations of clinical, histological and serological findings define clinical subtypes of CLE, yet there is high interindividual variation. Skin lesions arise in the course of triggers such as ultraviolet (UV) light exposure, smoking or drugs
Lupus erythematosus comprises a spectrum of autoimmune diseases that may affect various organs (systemic lupus erythematosus [SLE]) or the skin only (cutaneous lupus erythematosus [CLE]). Typical combinations of clinical, histological and serological findings define clinical subtypes of CLE, yet there is high interindividual variation. Skin lesions arise in the course of triggers such as ultraviolet (UV) light exposure, smoking or drugs
Uzrok lupus erythematosus nije jasan. Među jednojajčanim blizancima, ako je jedan pogođen, postoji 24% šanse da će i drugi biti pogođen. Vjeruje se da rizik povećavaju i ženski spolni hormoni, sunčeva svjetlost, pušenje, nedostatak vitamina D i određene infekcije.
Liječenje može uključivati NSAIL, kortikosteroide, imunosupresive, hidroksiklorokin i metotreksat. Iako su kortikosteroidi učinkoviti, dugotrajna primjena rezultira nuspojavama.