Onychomysosis - Gljivična Infekcija Noktiju
☆ U rezultatima Stiftung Warentest iz Njemačke za 2022., zadovoljstvo potrošača s ModelDermom bilo je samo malo niže nego s plaćenim konzultacijama o telemedicini.
Nokat na nozi zahvaćen Gljivična Infekcija Noktiju (Onychomysosis)
Stopala osobe s gljivičnom infekcijom noktiju nakon deset tjedana terapije oralnim lijekom terbinafinom. Zabilježite traku rasta zdravog nokta iza preostalih zaraženih noktiju.
References
Sistemski antifungici su najučinkovitije liječenje. Meta-analize pokazuju stope izlječenja gljivica kako slijedi: terbinafine = 76%, itraconazole with pulse dosing = 63%, itraconazole with continuous dosing = 59%, fluconazole =48% . Istodobni debridman nokta dodatno povećava stope izlječenja. Lokalna terapija ciclopirox je manje učinkovita; ima stopu kvarova veću od 60%.
Systemic antifungals are the most effective treatment. Meta-analyses shows mycotic cure rates as follows: terbinafine = 76%, itraconazole with pulse dosing = 63%, itraconazole with continuous dosing = 59%, fluconazole =48%. Concomitant nail debridement further increases cure rates. Topical therapy with ciclopirox is less effective; it has a failure rate exceeding 60%.
Systemic antifungals are the most effective treatment. Meta-analyses shows mycotic cure rates as follows: terbinafine = 76%, itraconazole with pulse dosing = 63%, itraconazole with continuous dosing = 59%, fluconazole =48%. Concomitant nail debridement further increases cure rates. Topical therapy with ciclopirox is less effective; it has a failure rate exceeding 60%.
Onihomikoza je gljivična infekcija koja zahvaća nokte. Kada je uzrokovana dermatofitima, naziva se tinea unguium. Onihomikoza uključuje infekcije uzrokovane dermatofitima, kvascima i plijesni. Problem s noktima koji nije uzrokovan gljivičnom infekcijom naziva se nail dystrophy. Iako može zahvatiti i nokte na rukama i nogama, onihomikoza noktiju na nogama je češća. Ovaj članak govori o različitim aspektima onihomikoze noktiju na nogama, kao što su njezin utjecaj, kliničke vrste, stadiji, dijagnoza i liječenje. Iako nije opasna po život, onihomikoza može dovesti do ozbiljnih komplikacija poput celulitisa, sepse, infekcije kostiju, oštećenja tkiva i gubitka noktiju.
Onychomycosis is a fungal infection of the nail unit. When dermatophytes cause onychomycosis, this condition is called tinea unguium. The term onychomycosis encompasses the dermatophytes, yeasts, and saprophytic mold infections. An abnormal nail not caused by a fungal infection is a dystrophic nail. Onychomycosis can infect both fingernails and toenails, but onychomycosis of the toenail is much more prevalent. Discussed in detail in this activity are all evolving facets of the topic, including disease burden, clinical types, staging, diagnosis, and management of toenail onychomycosis. While non-life-threatening, onychomycosis can lead to severe complications such as cellulitis, sepsis, osteomyelitis, tissue damage, and nail loss.
Onychomycosis is a fungal infection of the nail unit. When dermatophytes cause onychomycosis, this condition is called tinea unguium. The term onychomycosis encompasses the dermatophytes, yeasts, and saprophytic mold infections. An abnormal nail not caused by a fungal infection is a dystrophic nail. Onychomycosis can infect both fingernails and toenails, but onychomycosis of the toenail is much more prevalent. Discussed in detail in this activity are all evolving facets of the topic, including disease burden, clinical types, staging, diagnosis, and management of toenail onychomycosis. While non-life-threatening, onychomycosis can lead to severe complications such as cellulitis, sepsis, osteomyelitis, tissue damage, and nail loss.
Terbinafine je lijek koji se bori protiv gljivičnih infekcija blokiranjem skvalen epoksidaze. Djelotvoran je protiv mnogih vrsta kožnih gljivica i odobren je za liječenje gljivica na noktima kada se uzima oralno. Dok je većina nuspojava poput glavobolja i želučanih problema manja i prolazi sama od sebe, promjene okusa (disgeuzija) mogu varirati od blagih do teških, ponekad dovodeći do gubitka težine. Trajne promjene okusa su rijetke, ali su zabilježene.
Terbinafine is an antifungal medication that works through the inhibition of squalene epoxidase. It has activity against most dermatophytes, and it has approval for use as an oral therapy for the treatment of onychomycosis. Although most side effects are mild and self-limited, such as headache and gastrointestinal symptoms, taste disturbances (dysgeusia) can range from mild to severe, resulting in weight loss, and have rarely been reported permanent.
Terbinafine is an antifungal medication that works through the inhibition of squalene epoxidase. It has activity against most dermatophytes, and it has approval for use as an oral therapy for the treatment of onychomycosis. Although most side effects are mild and self-limited, such as headache and gastrointestinal symptoms, taste disturbances (dysgeusia) can range from mild to severe, resulting in weight loss, and have rarely been reported permanent.
Onihomikoza je gljivična infekcija koja zahvaća nokte. Oko 90% infekcija noktiju na nogama i 75% infekcija noktiju na rukama uzrokovano je gljivicama (Trichophyton mentagrophytes, Trichophyton rubrum) . Simptomi uključuju promjenu boje nokta, zadebljanje, odvajanje od ležišta nokta i prekomjerni rast. Liječenje obično uključuje oralne lijekove poput terbinafina ili itrakonazola, a lokalno liječenje je opcija za blage do umjerene slučajeve.
Onychomycosis is a fungal infection of the nail unit. Approximately 90% of toenail and 75% of fingernail onychomycosis are caused by dermatophytes, notably Trichophyton mentagrophytes and Trichophyton rubrum. Clinical manifestations include discoloration of the nail, subungual hyperkeratosis, onycholysis, and onychauxis. Currently, oral terbinafine is the treatment of choice, followed by oral itraconazole. In general, topical monotherapy can be considered for mild to moderate onychomycosis.
Onychomycosis is a fungal infection of the nail unit. Approximately 90% of toenail and 75% of fingernail onychomycosis are caused by dermatophytes, notably Trichophyton mentagrophytes and Trichophyton rubrum. Clinical manifestations include discoloration of the nail, subungual hyperkeratosis, onycholysis, and onychauxis. Currently, oral terbinafine is the treatment of choice, followed by oral itraconazole. In general, topical monotherapy can be considered for mild to moderate onychomycosis.
Čini se da je antifungalni lijek terbinafin koji se uzima na usta najučinkovitiji, ali terbinafin je povezan s nuspojavama na jetru.
gljivična infekcija noktiju (onychomysosis) se javlja u oko 10 posto odrasle populacije, a češće obolijevaju starije osobe. Muškarci su zahvaćeni češće nego žene. gljivična infekcija noktiju (onychomysosis) predstavlja oko polovicu bolesti noktiju. To znači da deformacija noktiju na nogama može biti uzrokovana i drugim uzrocima, a ne onihomikozom.
○ Liječenje ― OTC lijekovi
Teško je liječiti onihomikozu lokalnim lijekovima jer lijekovi teško prodiru kroz zadebljale nokte na nogama.
#Ketoconazole
#Clotrimazole
#Miconazole
#Terbinafine
#Butenafine [Lotrimin]
#Tolnaftate
○ Liječenje
Obično je potrebno dugotrajno liječenje sve dok se zaraženi nokat potpuno ne ukloni.
#Terbinafine (oral)
#Itraconazole
#Efinaconazole lacquer [Jublia]
#Ciclopirox lacquer