Prurigo nodularis - Nodularni Prurigo
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Prurigo nodularis je dugotrajno stanje kože obilježeno višestrukim čvrstim izbočinama i čvorovima, koji se obično nalaze na vanjskim dijelovima ruku i nogu. Ove izbočine mogu varirati u boji od tjelesne do ružičaste i jako svrbe. Mogu pogoditi ljude bilo koje dobi i često su povezani s drugim kožnim stanjima koja uzrokuju kronični svrbež, poput atopijskog dermatitisa. Mogućnosti liječenja uključuju jake lijekove protiv svrbeža, lijekove koji utječu na imunološki sustav i lijekove koji djeluju na živčani sustav. Liječenje prurigo nodularis obično uključuje dugotrajnu terapiju.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Liječenje obično uključuje korištenje krema ili injekcija steroida na zahvaćeno područje. U težim ili tvrdokornijim slučajevima mogu biti potrebni tretmani poput svjetlosne terapije ili lijekovi koji suzbijaju imunološki sustav. Talidomid i lenalidomid su opcije za teške slučajeve, ali mogu imati ozbiljne nuspojave. Noviji tretmani (opioid receptor antagonists, neurokinin-1 receptor antagonists) obećavaju u liječenju prurigo nodularis s manje nuspojava u usporedbi s talidomidom ili lenalidomidom.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Chronic prurigo je stanje kože karakterizirano dugotrajnim svrbežom (traje više od 6 tjedana) , kožnim lezijama povezanim s češanjem i poviješću učestalog češanja. Uključuje neuroinflamaciju i fibrozu kože.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Prurigo nodularis je dugotrajni kožni problem obilježen svrbežnim čvorićima. Ne znamo točno što ga uzrokuje, ali čini se da imunološki i živčani problemi igraju ulogu u ciklusu svrbeža i češanja. Trenutačno ne postoje nikakvi tretmani koje je FDA odobrila posebno za prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
○ Liječenje ― OTC lijekovi
Pranje područja lezije sapunom ne pomaže uopće i može pogoršati stanje. OTC steroidne masti mogu pomoći u ublažavanju simptoma, ali obično ih je potrebno primjenjivati nekoliko tjedana kako bi se popravili. Nastavak uzimanja antihistaminika također pomaže u ublažavanju svrbeža.
#OTC steroid ointment
#OTC antihistamine
○ Liječenje
#Intralesional triamcinolone injection