Staphylococcal scalded skin syndrome - Stafilokokni Sindrom Oparene Kože
https://en.wikipedia.org/wiki/Staphylococcal_scalded_skin_syndrome
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Dojenče s Stafilokokni Sindrom Oparene Kože (Staphylococcal scalded skin syndrome)

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References
Staphylococcal Scalded Skin Syndrome 28846262 NIH
Staphylococcal Scalded Skin Syndrome je stanje u kojem se koža ljušti zbog toksina koje proizvode određene vrste bakterije Staphylococcus. Rijetko je kod djece starije od šest godina. Može se pojaviti i kod odraslih s oslabljenim imunološkim sustavom ili ozbiljnim problemima s bubrezima. Glavna značajka je opsežno ljuštenje kože nakon upale. Ozbiljnost se kreće od nekoliko mjehurića do raširenog gubitka kože, što može uzrokovati ozbiljne padove tjelesne temperature i nestabilnost krvnog tlaka.
Staphylococcal Scalded Skin Syndrome is a disease characterized by denudation of the skin caused by exotoxin producing strains of the Staphylococcus species, typically from a distant site. It usually presents 48 hours after birth and is rare in children older than six years. It may also present in immunocompromised adults or those with severe renal disease. The disorder is characterized by significant exfoliation of skin following cellulitis. The severity may vary from a few blisters to system exfoliation leading to marked hypothermia and hemodynamic instability.
Staphylococcal Scalded Skin Syndrome and Bullous Impetigo 34833375 NIH
Staphylococcal scalded skin syndrome (SSSS) and bullous impetigo are infections caused by Staphylococcus aureus. Bullous impetigo is due to the local release of these toxins and thus, often presents with localized skin findings, whereas SSSS is from the systemic spread of these toxins, resulting in a more generalized rash and severe presentation. Both conditions are treated with antibiotics that target S. aureus. These conditions can sometimes be confused with other conditions that result in superficial blistering.
Staphylococcal Scalded Skin Syndrome in a Ten-Month-Old Male - Case reports 35989790 NIH
Dječak od 10 mjeseci došao je s curenjem iz nosa i loše jede. Doktori su rekli da se radi o infekciji gornjih dišnih puteva. Dva dana kasnije vratio se jer mu nije bilo bolje i imao je nove probleme poput natečenog lica i nadražene kože oko usta. Tijekom sljedeća dva dana dječaku je bilo sve gore. Ruke i noge su mu natekle, a koža mu se počela skidati. U bolnici su liječnici primijetili crveni osip na njegovom licu i u naborima kože, koji je blijedio na dodir. Dijagnosticirali su mu staphylococcal scalded skin syndrome (SSSS) i stavili mu antibiotike kroz venu.
A 10-month-old male presented with rhinorrhea and decreased oral intake and was diagnosed with an upper respiratory infection. Two days later, he returned to the clinic due to a lack of improvement and the onset of new symptoms, including facial edema and perioral skin irritation. That evening, he became febrile at 100.4 °F and went to the emergency department at the local children's hospital. No further workup was done and the parents were instructed to continue with the current treatment regimen. Over the next 48 hours, the patient's symptoms worsened with the new onset of bilateral extremity edema and desquamation. The patient was returned to the emergency department. A physical exam was notable for a blanching, desquamating, erythematous rash on the face and creases of the arms, legs, and groin. A positive Nikolsky sign was reported. A clinical diagnosis of staphylococcal scalded skin syndrome (SSSS) was made, and the patient was started on intravenous clindamycin. This case illustrates a severe presentation of SSSS in a pediatric patient, demonstrating the challenges it poses to diagnosis and treatment.
Staphylococcal scalded skin syndrome - Case reports 23761500 NIH
Dvogodišnja djevojčica pojavila se s osipom po cijelom tijelu koji se razvijao tijekom 48 sati, nakon uboda insekata na licu dan ranije. Tijekom pregleda imala je rašireni osip sastavljen od malih kvržica koje su se spajale, a kada se lagano trljala, koža joj je pokazivala znakove Nikolskog znaka. Nije bilo znakova osipa na njezinoj sluznici. Testovi njezine krvi nisu pokazali nikakve znakove infekcije.
A 2-year-old girl presented a generalised rash with 48 h of evolution, in the context of insect bites on the face on the day before. At observation, she had a generalised micropapular rash with confluent areas and Nikolsky sign. There was no mucosal area affected. Blood cultures were negative.
Sindrom je izazvan epidermolitičkim egzotoksinima (exfoliatin)A i B, koje oslobađa S. aureus. Prognoza stafilokokni sindrom oparene kože (staphylococcal scalded skin syndrome) u djece je izvrsna, s potpunim povlačenjem unutar 10 dana od liječenja i bez značajnih ožiljaka. Međutim, stafilokokni sindrom oparene kože (staphylococcal scalded skin syndrome) mora se pažljivo razlikovati od toksične epidermalne nekrolize, koja ima lošu prognozu.
○ Dijagnostika i liječenje
Pogrešna dijagnoza kao lezije ekcema kao što je atopijski dermatitis i primjena steroidne masti pogoršava lezije. Molimo potražite liječničku pomoć što je prije moguće dok nanosite antibiotsku mast.
#Bacitracin
#First-generation cephalosporins (e.g. Cefradine)
#Bacterial culture
#Third-generation cephalosporins (e.g. Cefditoren Pivoxil)