Syphilis - Sifilis
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Chancres ― primarna sifilitička infekcija od Treponema pallidum
References
Sifilis je spolno prenosiva bolest koju uzrokuje bakterija Treponema pallidum. U ovoj studiji usredotočili smo se na 57 pacijenata u dobi od 18 do 68 godina sa sekundarnim sifilisom.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
Sifilis je bakterijska infekcija koju uzrokuje Treponema pallidum. Može oponašati razne bolesti, zbog čega je dobio nadimak great imitator. Sifilis još uvijek pogađa milijune diljem svijeta, ali se može učinkovito liječiti penicilinom.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Treponema pallidum uzrokuje sifilis putem seksualnog kontakta ili s majke na bebu tijekom trudnoće. Iako postoje jednostavni testovi za dijagnosticiranje i liječenje jednom injekcijom dugodjelujućeg penicilina dobro funkcionira, sifilis ponovno postaje veliki problem diljem svijeta. To se posebno odnosi na muškarce koji imaju spolne odnose s muškarcima (MSM) u zemljama s visokim i srednjim prihodima. Dok su neke zemlje s niskim prihodima ispunile ciljeve Svjetske zdravstvene organizacije da zaustave prijenos sifilisa s majke na bebu, postoji zabrinjavajući porast sifilisa među HIV pozitivnim MSM-om.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
(1) Povećana jetra: Ovo se često nalazi i može se dogoditi uz povećanu slezenu. Ispitivanje biopsije jetre pod mikroskopom tamnog polja može otkriti prisutnost spirohete. Testovi funkcije jetre mogu pokazati abnormalnosti. (2) Žutilo kože (žutica) : Hoće li netko imati žuticu ovisi o tome koliko je zahvaćena jetra. (3) Curenje iz nosa: Često jedan od prvih znakova, obično unutar prvog tjedna nakon rođenja. (4) Natečeni limfni čvorovi: Generalizirano oticanje limfnih čvorova, obično bezbolno, također je često. (5) Osip na koži: Osip se obično pojavljuje jedan do dva tjedna nakon curenja nosa. Možete vidjeti male crvene ili ružičaste mrlje na leđima, stražnjici, bedrima i tabanima. Ovaj osip može napredovati do ljuštenja i stvaranja krasta.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
○ Dijagnostika i liječenje
VDRL i RPR mogu se koristiti za potvrdu nedavne infekcije i provjeru sifilisa. FTA-ABS test je specifičniji test i može se koristiti za provjeru prethodne infekcije. Penicilin se koristi za liječenje sifilisa.