Plis enfomasyon ― Kreyòl ayisyen

Cutaneous angiofibromas ka parèt nan divès pati nan kò a. Sou figi a, yo souvan ke yo rekonèt kòm papul fib oswa adenom sebaseum; sou pati gason yo, yo rele pearly penile papules ; anba klou a, yo rele yo angiofibrom periungual oswa timè Koenen; ak nan bouch la, yo refere yo kòm fibrom oral. Angiofibrom fasyal yo se yon karakteristik enpòtan nan tuberous sclerosis (TS) , yon maladi eritye ki afekte po a, ren, kè, sèvo, ak poumon. Yo anjeneral devlope sou figi a pandan anfans oswa adilt bonè nan moun ki gen TS. Gen twa oswa plis angiofibrom feminen oswa de oswa plis angiofibrom periungual konsidere kòm enpòtan nan dyagnostik TS. Anplis de sa, plizyè angiofibrom feminen ka prezan nan kondisyon (multiple endocrine neoplasia type 1 (MEN-1) ak Birt-Hogg-Dubé syndrome) . Pearly penile papules yo jwenn sou maj koronèl la ak sulcus penis la. Yo se pèsistan, boul san doulè pi souvan wè nan gason ki pa sikonsi.
Cutaneous angiofibromas can be located on different areas of the body including the face where they are commonly called fibrous papules or adenoma sebaceum on the penis where they are called pearly penile papules, underneath the nail where they are called periungual angiofibromas or Koenen tumors, and in the mouth where they are called oral fibromas. Facial angiofibromas are considered one of the most obvious clinical presentations of tuberous sclerosis (TS), an autosomal dominant hamartomatous disorder that affects the skin, kidneys, heart, brain, and lungs. With TS, angiofibromas typically arise on the face in childhood and early adulthood. Both facial angiofibromas (greater than or equal to 3 needed) and periungual angiofibroma (greater than or equal to 2 needed) are 2 of the major criteria for TS. Multiple facial angiofibromas are also found in multiple endocrine neoplasia type 1 (MEN-1) and Birt-Hogg-Dube syndrome. Pearly penile papules are chronic, asymptomatic, papules found on the coronal margin and sulcus of the penis. They are more common in uncircumcised men.