Porokeratosis - Porokeratoz
☆ Nan rezilta Stiftung Warentest 2022 ki soti nan Almay, satisfaksyon konsomatè yo ak ModelDerm te sèlman yon ti kras pi ba pase ak konsiltasyon telemedsin peye.
Bor yo difisil ki vle pèse anvlòp yo se karakteristik.
References
Porokeratosis se yon kondisyon po ki ra ki karakterize pa pwoblèm keratinizasyon, sa ki lakòz plak ki gen fòm bag oswa boul ki graj sou po a. Karakteristik defini li yo anba mikwoskòp la se prezans nan lamèl kornoid, yon aranjman espesifik nan selil nan kouch anwo po a. Porokeratosis vini sou plizyè fòm (disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, linear porokeratosis) . Li enpòtan sonje ke porokeratosis ka potansyèlman devlope nan kansè po. Pi bon fason pou fè dyagnostik porokeratosis se atravè yon byopsi sou fwontyè ki monte a, menmsi pa gen okenn pwotokòl tretman estanda kounye a.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Disseminated superficial actinic porokeratosis (DSAP) se yon maladi keratinizasyon dezòd. Li se youn nan sis kalite porokeratoz, epi li anjeneral afekte pi gwo zòn konpare ak lòt yo (linear, Mibelli's, punctate, palmoplantar disseminated, superficial porokeratosis) . Kalite eruptive porokeratoz souvan lye ak kansè, iminite febli, oswa enflamasyon. Faktè risk yo enplike jenetik, repwesyon iminitè, ak ekspoze solèy la. DSAP kòmanse kòm boul woz oswa mawon ak kwen ki wo nan zòn ki ekspoze a solèy, pafwa lakòz yon ti demanjezon. Tretman yo varye epi yo ka gen ladan krèm aktualite, terapi limyè, oswa medikaman tankou 5-fluorouracil oswa retinoid. Yo konsidere blesi sa yo prekansè, ak yon 7. 5 - 10 % chans pou yo tounen nan selil squamous oswa nan selil basal.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Yon nonm 52-zan, ki te deja an sante, te antre ak yon plak plat, ki gen fòm bag nan fen katriyèm zòtèy li, ki te la pou 2 ane san yo pa lakòz okenn sentòm. Li te kòmanse kòm yon ti boul difisil epi li te grandi deyò sou tan. Malgre ke yo te eseye plizyè tretman tankou kriyoterapi, krèm, antifonjik, ak antibyotik, patch la pa t 'jwenn pi bon. Egzamine li byen ak yon dermokopsy te montre yon sant sèk, wouj ak yon fwontyè epè, ki graj. Yon ti moso po te pran nan kwen plak la te montre kwasans selil nòmal nan kouch ekstèn po a, ki konfime yon dyagnostik porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
Souvan yo fè yon byopsi paske li ka sanble ak keratoz aktinik oswa karsinom selil squamous.