Acute generalized exanthematous pustulosis - Pustulosis Eksantematosa Umum Akut
Pustulosis Eksantematosa Umum Akut (Acute generalized exanthematous pustulosis) (AGEP) adalah reaksi kulit langka yang 90% kasusnya berhubungan dengan pemberian obat. pustulosis eksantematosa umum akut (acute generalized exanthematous pustulosis) ditandai dengan erupsi kulit mendadak yang muncul rata-rata lima hari setelah pengobatan dimulai. Letusan tersebut berupa pustula, yaitu erupsi kecil berwarna merah putih atau merah pada kulit yang mengandung bahan keruh atau bernanah (nanah). Lesi kulit biasanya sembuh dalam 1-3 hari setelah penghentian pengobatan yang menyebabkan penyakit.
☆ Pada hasil Stiftung Warentest tahun 2022 dari Jerman, kepuasan konsumen terhadap ModelDerm hanya sedikit lebih rendah dibandingkan dengan konsultasi telemedis berbayar.
Lesi luas disertai eritema dan pustula muncul secara tiba-tiba.
References
Acute generalized exanthematous pustulosis (AGEP) adalah reaksi kulit yang ditandai dengan benjolan kecil berisi nanah di dasar kulit yang berwarna merah. Biasanya terjadi ketika seseorang mengonsumsi obat tertentu, seperti antibiotik, dan menyebar dengan cepat ke seluruh tubuh. Setelah menghentikan obat pemicunya, gejalanya biasanya hilang dalam waktu dua minggu, seringkali meninggalkan sedikit pengelupasan kulit. Meskipun biasanya tidak serius dan terbatas pada kulit, kasus yang parah dapat diklasifikasikan bersamaan dengan reaksi kulit serius lainnya seperti Stevens-Johnson syndrome atau toxic epidermal necrolysis. Perawatan utamanya adalah perawatan suportif, dan prognosis untuk penyembuhan penyakit secara menyeluruh biasanya sangat baik.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
Seorang laki-laki berusia 76 tahun datang ke IGD karena kulitnya mengalami perubahan dalam dua hari terakhir. Dokter menemukan bercak merah dan area menonjol di badan, lengan, dan kakinya. Seiring berjalannya waktu, bercak-bercak ini menyatu, dan ia mengembangkan benjolan seperti jerawat di area merah. Tes menunjukkan jumlah sel darah putih yang tinggi dengan banyak jenis yang disebut neutrofil, dan peningkatan kadar C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
