Onychomysosis - Onikomikosis
☆ Pada hasil Stiftung Warentest tahun 2022 dari Jerman, kepuasan konsumen terhadap ModelDerm hanya sedikit lebih rendah dibandingkan dengan konsultasi telemedis berbayar.
Kuku kaki terkena Onikomikosis (Onychomysosis)
Kaki seseorang dengan infeksi jamur kuku sepuluh minggu setelah menjalani pengobatan oral terbinafine. Perhatikan pita pertumbuhan kuku yang sehat di belakang sisa kuku yang terinfeksi.
References
Antijamur sistemik adalah pengobatan yang paling efektif. Meta-analisis menunjukkan angka kesembuhan mikotik sebagai berikut: terbinafine = 76%, itraconazole with pulse dosing = 63%, itraconazole with continuous dosing = 59%, fluconazole =48% . Debridemen kuku secara bersamaan semakin meningkatkan angka kesembuhan. Terapi topikal dengan ciclopirox kurang efektif; ia memiliki tingkat kegagalan melebihi 60%.
Systemic antifungals are the most effective treatment. Meta-analyses shows mycotic cure rates as follows: terbinafine = 76%, itraconazole with pulse dosing = 63%, itraconazole with continuous dosing = 59%, fluconazole =48%. Concomitant nail debridement further increases cure rates. Topical therapy with ciclopirox is less effective; it has a failure rate exceeding 60%.
Systemic antifungals are the most effective treatment. Meta-analyses shows mycotic cure rates as follows: terbinafine = 76%, itraconazole with pulse dosing = 63%, itraconazole with continuous dosing = 59%, fluconazole =48%. Concomitant nail debridement further increases cure rates. Topical therapy with ciclopirox is less effective; it has a failure rate exceeding 60%.
Onikomikosis adalah infeksi jamur yang menyerang kuku. Jika disebabkan oleh dermatofita disebut tinea unguium. Onikomikosis mencakup infeksi yang disebabkan oleh dermatofita, jamur, dan jamur. Masalah kuku yang bukan disebabkan oleh infeksi jamur disebut nail dystrophy. Meskipun dapat menyerang kuku jari tangan dan kaki, onikomikosis kuku kaki lebih sering terjadi. Artikel ini membahas berbagai aspek onikomikosis kuku kaki, seperti dampaknya, tipe klinis, stadium, diagnosis, dan pengobatan. Meskipun tidak mengancam jiwa, onikomikosis dapat menyebabkan komplikasi serius seperti selulitis, sepsis, infeksi tulang, kerusakan jaringan, dan kehilangan kuku.
Onychomycosis is a fungal infection of the nail unit. When dermatophytes cause onychomycosis, this condition is called tinea unguium. The term onychomycosis encompasses the dermatophytes, yeasts, and saprophytic mold infections. An abnormal nail not caused by a fungal infection is a dystrophic nail. Onychomycosis can infect both fingernails and toenails, but onychomycosis of the toenail is much more prevalent. Discussed in detail in this activity are all evolving facets of the topic, including disease burden, clinical types, staging, diagnosis, and management of toenail onychomycosis. While non-life-threatening, onychomycosis can lead to severe complications such as cellulitis, sepsis, osteomyelitis, tissue damage, and nail loss.
Onychomycosis is a fungal infection of the nail unit. When dermatophytes cause onychomycosis, this condition is called tinea unguium. The term onychomycosis encompasses the dermatophytes, yeasts, and saprophytic mold infections. An abnormal nail not caused by a fungal infection is a dystrophic nail. Onychomycosis can infect both fingernails and toenails, but onychomycosis of the toenail is much more prevalent. Discussed in detail in this activity are all evolving facets of the topic, including disease burden, clinical types, staging, diagnosis, and management of toenail onychomycosis. While non-life-threatening, onychomycosis can lead to severe complications such as cellulitis, sepsis, osteomyelitis, tissue damage, and nail loss.
Terbinafine adalah obat yang melawan infeksi jamur dengan memblokir squalene epoxidase. Ini efektif melawan banyak jenis jamur kulit dan disetujui untuk mengobati jamur kuku bila dikonsumsi secara oral. Meskipun sebagian besar efek samping seperti sakit kepala dan masalah perut bersifat ringan dan hilang dengan sendirinya, perubahan rasa (dysgeusia) dapat bervariasi dari ringan hingga parah, terkadang menyebabkan penurunan berat badan. Perubahan rasa permanen jarang terjadi tetapi telah dilaporkan.
Terbinafine is an antifungal medication that works through the inhibition of squalene epoxidase. It has activity against most dermatophytes, and it has approval for use as an oral therapy for the treatment of onychomycosis. Although most side effects are mild and self-limited, such as headache and gastrointestinal symptoms, taste disturbances (dysgeusia) can range from mild to severe, resulting in weight loss, and have rarely been reported permanent.
Terbinafine is an antifungal medication that works through the inhibition of squalene epoxidase. It has activity against most dermatophytes, and it has approval for use as an oral therapy for the treatment of onychomycosis. Although most side effects are mild and self-limited, such as headache and gastrointestinal symptoms, taste disturbances (dysgeusia) can range from mild to severe, resulting in weight loss, and have rarely been reported permanent.
Onikomikosis adalah infeksi jamur yang menyerang kuku. Sekitar 90% infeksi kuku kaki dan 75% infeksi kuku jari tangan disebabkan oleh jamur (Trichophyton mentagrophytes, Trichophyton rubrum) . Gejalanya meliputi perubahan warna kuku, penebalan, terpisah dari dasar kuku, dan pertumbuhan berlebih. Perawatan biasanya melibatkan obat-obatan oral seperti terbinafine atau itraconazole, dengan perawatan topikal menjadi pilihan untuk kasus ringan hingga sedang.
Onychomycosis is a fungal infection of the nail unit. Approximately 90% of toenail and 75% of fingernail onychomycosis are caused by dermatophytes, notably Trichophyton mentagrophytes and Trichophyton rubrum. Clinical manifestations include discoloration of the nail, subungual hyperkeratosis, onycholysis, and onychauxis. Currently, oral terbinafine is the treatment of choice, followed by oral itraconazole. In general, topical monotherapy can be considered for mild to moderate onychomycosis.
Onychomycosis is a fungal infection of the nail unit. Approximately 90% of toenail and 75% of fingernail onychomycosis are caused by dermatophytes, notably Trichophyton mentagrophytes and Trichophyton rubrum. Clinical manifestations include discoloration of the nail, subungual hyperkeratosis, onycholysis, and onychauxis. Currently, oral terbinafine is the treatment of choice, followed by oral itraconazole. In general, topical monotherapy can be considered for mild to moderate onychomycosis.
Obat antijamur terbinafine yang diminum tampaknya paling efektif tetapi terbinafine dikaitkan dengan efek samping hati.
onikomikosis (onychomysosis) terjadi pada sekitar 10 persen populasi orang dewasa, dan orang lanjut usia lebih sering terkena. Laki-laki lebih sering terkena dibandingkan perempuan. onikomikosis (onychomysosis) mewakili sekitar setengah dari penyakit kuku. Artinya, kelainan bentuk kuku kaki juga bisa disebabkan oleh penyebab lain selain onikomikosis.
○ Pengobatan - Obat OTC
Sulitnya mengobati onikomikosis dengan obat topikal karena obat sulit menembus kuku kaki yang menebal.
#Ketoconazole
#Clotrimazole
#Miconazole
#Terbinafine
#Butenafine [Lotrimin]
#Tolnaftate
○ Perlakuan
Perawatan jangka panjang biasanya diperlukan sampai kuku kaki yang terinfeksi benar-benar hilang.
#Terbinafine (oral)
#Itraconazole
#Efinaconazole lacquer [Jublia]
#Ciclopirox lacquer