Acute generalized exanthematous pustulosis
Acute generalized exanthematous pustulosis (AGEP) bụ mmeghachi omume anụ ahụ na-adịghị ahụkebe nke na 90% nke ikpe metụtara nchịkwa ọgwụ. Acute generalized exanthematous pustulosis bụ mgbawa akpụkpọ anụ na mberede na-apụta na nkezi ụbọchị ise ka amalitere ọgwụ. Ihe mgbawa ndị a bụ pustules, ya bụ obere ocha na-acha uhie uhie ma ọ bụ na-acha uhie uhie nke akpụkpọ ahụ nwere urukpuru ma ọ bụ purulent (pus). Ọnya akpụkpọ ahụ na-edozikarị n'ime ụbọchị 1-3 nke ịkwụsị ọgwụ ọjọọ ahụ.
☆ Na nsonaazụ Stiftung Warentest nke 2022 sitere na Germany, afọ ojuju ndị ahịa na ModelDerm dị ntakịrị ntakịrị karịa na nyocha telemedicine akwụ ụgwọ.
Ọnya zuru ebe niile nwere erythema na pustules na-apụta na mberede.
References
Acute generalized exanthematous pustulosis (AGEP) bụ mmeghachi omume akpụkpọ ahụ nke nwere obere ọnya juru na isi akpụkpọ ahụ na-acha ọbara ọbara. Ọ na-emekarị mgbe mmadụ na-aṅụ ọgwụ ụfọdụ, dị ka ọgwụ nje, na-agbasa ngwa ngwa n'ime ahụ. Mgbe ịkwụsị ọgwụ na-akpali akpali, mgbaàmà na-apụkarị n'ime izu abụọ, na-ahapụkarị akpụkpọ ahụ. Ọ bụ ezie na ọ bụghị ihe siri ike ma na-ejedebe na akpụkpọ ahụ, enwere ike ịmekọrịta ikpe siri ike yana mmeghachi omume akpụkpọ anụ ndị ọzọ dị ka Stevens-Johnson syndrome ma ọ bụ toxic epidermal necrolysis. Ọgwụgwọ bụ nlekọta na-akwado nkwado, na prognosis maka mkpebi zuru oke nke ọrịa na-adịkarị mma.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
Otu nwoke dị afọ 76 bịara n'ọnụ ụlọ mberede n'ihi na akpụkpọ ahụ ya agbanweela n'ime ụbọchị abụọ gara aga. Ndị dọkịta chọtara patches na-acha uhie uhie na ebe a na-ebuli elu na ogwe ya na ogwe aka na ụkwụ ya. Ka oge na-aga, patches ndị a jikọtara ọnụ, o wee malite mkpọmkpọtụ dị ka pimple na mpaghara uhie. Nnwale gosipụtara ọnụ ọgụgụ sel ọcha dị elu nwere ọtụtụ ụdị a na-akpọ neutrophils, yana mmụba nke ọkwa C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
