Onychomysosishttps://en.wikipedia.org/wiki/Onychomycosis
Onychomycosis bụ ọrịa fungal nke ntu. Mgbaàmà nwere ike ịgụnye ntu nwere agba ọcha ma ọ bụ odo, ntu na-aghọ mgbagwoju, na ikewapụ ntu na akwa ntu. Enwere ike imetụta mbọ ụkwụ ma ọ bụ mbọ aka, mana ọ na-adịkarị n’mbọ ụkwụ. Ihe mgbagwoju anya nwere ike ịgụnye cellulitis nke ụkwụ ala. Ọtụtụ ụdị fungi dị iche iche nwere ike ịkpata onychomycosis, gụnyere dermatophytes. Ihe ize ndụ gụnyere ụkwụ ndị na-eme egwuregwu, ọrịa ntu ndị ọzọ, ikpughe onye nwere ọnọdụ ahụ, ọrịa vaskụla, na ọrụ nchebe na-adịghị mma.

Ọgwụ antifungal terbinafine a na-ewere n’ọnụ yiri ka ọ kacha dị irè, ma ọ nwere ike ibute mmetụta n’akụkụ imeju.

Onychomycosis na-eme n’ihe dị ka pasent 10 nke ndị okenye, ma ndị agadi na-emetụtakwa ya. A na-ahụkarị ya n’ịkpa ụmụ nwoke karịa ụmụ nwanyị. Onychomycosis na-anọchi anya ihe dị ka ọkara nke ọrịa ntu niile. Nke a pụtara na mmebi nke mbọ ụkwụ nwekwara ike ịbụ n’ihi ihe ndị ọzọ karịa onychomycosis.

Ọgwụgwọ – Ọgwụ OTC
Ọ siri ike ịgwọ onychomycosis na ọgwụ ndị dị n’akụkụ n’ihi na ọ na-esiri ọgwụ ike ịbanye n’ime mbọ ụkwụ gbajiri agbaze.
#Ketoconazole
#Clotrimazole
#Miconazole
#Terbinafine
#Butenafine [Lotrimin]
#Tolnaftate

Ọgwụgwọ
A na-achọkarị ọgwụgwọ ogologo oge ruo mgbe a na-ewepụ ntu ahụ kpamkpam.
#Terbinafine (oral)
#Itraconazole
#Efinaconazole lacquer [Jublia]
#Ciclopirox lacquer
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  • Mbọ ụkwụ Onychomycosis metụtara ya aka.
  • Ụkwụ mmadụ nwere ọrịa ntu fungal maka izu iri n'ime usoro ọgwụgwọ oral nke terbinafine. Rịba ama na eriri ntu ahụ dị mma n'azụ ntu nje ndị fọdụrụ.
  • Ihe gbasara ọrịa fungal n'ukwu ukwu.
References Onychomycosis: Current trends in diagnosis and treatment 24364524
Usoro ọgwụgwọ antifungal bụ nke kachasị dị irè. Meta‑analyses na-egosi ọnụego ọgwụgwọ mycotic dị ka ndị a: terbinafine = 76%, itraconazole with pulse dosing = 63%, itraconazole with continuous dosing = 59%, fluconazole = 48% . Ntụ ntị na-ejikọta ọnụ na-abawanye ọnụego ọgwụgwọ. Usoro ọgwụgwọ ciclopirox adịghị arụ ọrụ nke ọma; ọ nwere ọnụego ọdịda karịrị 60%.
Systemic antifungals are the most effective treatment. Meta-analyses shows mycotic cure rates as follows: terbinafine = 76%, itraconazole with pulse dosing = 63%, itraconazole with continuous dosing = 59%, fluconazole =48%. Concomitant nail debridement further increases cure rates. Topical therapy with ciclopirox is less effective; it has a failure rate exceeding 60%.
 Onychomycosis 28722883 
NIH
Onychomycosis bụ ọrịa fungal nke na-emetụta mbọ. Mgbe dermatophytes kpatara ya, a na-akpọ ya tinea unguium. Onychomycosis gụnyere ọrịa nke dermatophytes, yeasts, na bacteria kpatara. Nsogbu n’akpụkpọ ụkwụ nke ọrịa fungal na-akpata akpọrọ nail dystrophy. Ọ bụ ezie na ọ nwere ike imetụta ma mbọ aka na mbọ ụkwụ, onychomycosis na-akarịkarị. Edemede a na-atụle akụkụ dị iche iche nke onychomycosis n’akpụkpọ ụkwụ, dị ka mmetụta ya, ụdị ụlọ ọgwụ, ọkwa, nyocha na ọgwụgwọ. Ọ bụ ezie na ọ bụghị ihe na-eyi ndụ egwu, onychomycosis nwere ike ịkpata nsogbu siri ike dị ka cellulitis, sepsis, ọrịa ọkpụkpụ, mmebi anụ ahụ, na ntu ntu.
Onychomycosis is a fungal infection of the nail unit. When dermatophytes cause onychomycosis, this condition is called tinea unguium. The term onychomycosis encompasses the dermatophytes, yeasts, and saprophytic mold infections. An abnormal nail not caused by a fungal infection is a dystrophic nail. Onychomycosis can infect both fingernails and toenails, but onychomycosis of the toenail is much more prevalent. Discussed in detail in this activity are all evolving facets of the topic, including disease burden, clinical types, staging, diagnosis, and management of toenail onychomycosis. While non-life-threatening, onychomycosis can lead to severe complications such as cellulitis, sepsis, osteomyelitis, tissue damage, and nail loss.
 Terbinafine 31424802 
NIH
Terbinafine bụ ọgwụ na-alụ ọgụ megide ọrịa fungal site n'ịgbachi squalene epoxidase. Ọ dị irè megide ọtụtụ ụdị fungi anụ ahụ ma kwado ya maka ọgwụgwọ ero ntu mgbe a na-e ya ọnụ. Ọ bụ ezie na mmetụta ndị dị ka isi ọwụwa na ihe gbasara afọ dị obere ma na-apụ n'onwe ha, mgbanwe na uto (dysgeusia) nwere ike ịdịgasị iche site n'ịdị nwayọọ ruo n'ịdị njọ, mgbe ụfọdụ na-eduga ná nkwụsị. Mgbanwe uto a na-adịgide adịgide dị ntakịrị, mana a kọwawo ya.
Terbinafine is an antifungal medication that works through the inhibition of squalene epoxidase. It has activity against most dermatophytes, and it has approval for use as an oral therapy for the treatment of onychomycosis. Although most side effects are mild and self-limited, such as headache and gastrointestinal symptoms, taste disturbances (dysgeusia) can range from mild to severe, resulting in weight loss, and have rarely been reported permanent.
 Onychomycosis: An Updated Review 31738146 
NIH
Onychomycosis bụ ọrịa fungal nke na-emetụta mbọ. Ihe dị ka 90% nke ọrịa ntu na 75% nke ntu mkpịsị aka na-ebute fungi (Trichophyton mentagrophytes, Trichophyton rubrum). Mgbaàmà na-agụnye agba ntu, ntu, ikewapụ n'àkwà ntu, na oke ibu. Ọgwụgwọ na-agụnyekarị ọgwụ oral dị ka terbinafine ma ọ bụ itraconazole, yana ọgwụgwọ ndị dị n'elu bụ nhọrọ maka ikpe dị nro ma na-agafeghị oke.
Onychomycosis is a fungal infection of the nail unit. Approximately 90% of toenail and 75% of fingernail onychomycosis are caused by dermatophytes, notably Trichophyton mentagrophytes and Trichophyton rubrum. Clinical manifestations include discoloration of the nail, subungual hyperkeratosis, onycholysis, and onychauxis. Currently, oral terbinafine is the treatment of choice, followed by oral itraconazole. In general, topical monotherapy can be considered for mild to moderate onychomycosis.