Toxic epidermal necrosis
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Njirimara akpụkpọ ahụ nke Toxic epidermal necrosis
relevance score : -100.0%
ReferencesStevens-Johnson Syndrome (SJS) na Toxic Epidermal Necrolysis (TEN) bụ ọnọdụ dị ụkọ ebe akpụkpọ ahụ na-enweta nnukwu necrosis na mwụfu. N'ihe gbasara ọgwụgwọ, cyclosporine na-arụ ọrụ nke ọma maka SJS, ebe ngwakọta nke immunoglobulin intravenous (IVIg) na corticosteroids na-arụ ọrụ kacha mma maka SJS na TEN.
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin. Regarding treatment, cyclosporine is the most effective therapy for the treatment of SJS, and a combination of intravenous immunoglobulin (IVIg) and corticosteroids is most effective for SJS/TEN overlap and TEN.
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin. Regarding treatment, cyclosporine is the most effective therapy for the treatment of SJS, and a combination of intravenous immunoglobulin (IVIg) and corticosteroids is most effective for SJS/TEN overlap and TEN.
Toxic epidermal necrolysis (TEN) bụ mmeghachi omume anụ ahụ siri ike nke ụfọdụ ọgwụ na arụ ọrụ sistemu ahụ ji alụso ọrịa ọgụ na-ebute, na-ebute nnukwu mwepu nke elu akpụkpọ anụ ahụ (epidermis), na-emetụta ihe karịrị 30% nke elu ahụ. TEN nwere ọnụ ọgụgụ ọnwụ karịrị 20%, ọtụtụ mgbe n'ihi ọrịa na nsogbu iku ume. Ịkwụsị ọgwụ na-akpata mmeghachi omume, inye nkwado, na iji ọgwụgwọ ndị ọzọ nwere ike imeziwanye ihe ga-esi na ya pụta. Nnyocha e mere n'oge na-adịbeghị anya egosila na ọgwụ ndị dị ka cyclosporine, tumor necrosis factor alpha inhibitors, na nchikota nke intravenous immunoglobulin (IVIg) na corticosteroids nwere ike inye aka, dabere na ule ndị a na-achịkwa na nyocha nke ọtụtụ ọmụmụ.
Toxic epidermal necrolysis (TEN) is a serious skin reaction caused by certain medications and immune system activity, resulting in large-scale detachment of the outer skin layer (epidermis), affecting more than 30% of the body's surface. TEN has a mortality rate of over 20%, often due to infections and breathing difficulties. Stopping the medication causing the reaction, providing supportive care, and using additional treatments can improve the outcome. Recent studies have shown that drugs like cyclosporine, tumor necrosis factor alpha inhibitors, and a combination of intravenous immune globulin and corticosteroids can be helpful, based on randomized controlled trials and analyses of multiple studies.
Toxic epidermal necrolysis (TEN) is a serious skin reaction caused by certain medications and immune system activity, resulting in large-scale detachment of the outer skin layer (epidermis), affecting more than 30% of the body's surface. TEN has a mortality rate of over 20%, often due to infections and breathing difficulties. Stopping the medication causing the reaction, providing supportive care, and using additional treatments can improve the outcome. Recent studies have shown that drugs like cyclosporine, tumor necrosis factor alpha inhibitors, and a combination of intravenous immune globulin and corticosteroids can be helpful, based on randomized controlled trials and analyses of multiple studies.
Recent Advances: There is improved understanding of pain and morbidity with regard to the type and frequency of dressing changes. More modern dressings, such as nanocrystalline, are currently favored as they may be kept in situ for longer periods. The most recent evidence on systemic agents, such as corticosteroids and cyclosporine, and novel treatments, are also discussed.
Ihe na-akpatakarị bụ ọgwụ ụfọdụ dị ka lamotrigine, carbamazepine, allopurinol, sulfonamide antibiotics, na nevirapine. Ihe ndị dị ize ndụ gụnyere HIV infection na systemic lupus erythematosus. Ọgwụgwọ na-ewerekarị ọnọdụ n'ụlọ ọgwụ dịka na ngalaba ọkụ ma ọ bụ ngalaba nlekọta ahụike.
○ Ọgwụgwọ
Nke a bụ ọrịa siri ike, yabụ ọ bụrụ na egbugbere ọnụ gị ma ọ bụ ọnụ gị emetụta ma ọ bụ ọnya gị agbawara, hụ dọkịta gị ozugbo.
Ekwesịrị ịkwụsị ọgwụ enyo enyo. (dịka ọmụmaatụ, antibiotics, non‑steroidal anti‑inflammatory drugs)