Acute generalized exanthematous pustulosis - Bráð Almenn Exanthematous Pustulosis
Bráð Almenn Exanthematous Pustulosis (Acute generalized exanthematous pustulosis) (AGEP) er sjaldgæf húðviðbrögð sem í 90% tilfella tengjast lyfjagjöf. bráð almenn exanthematous pustulosis (acute generalized exanthematous pustulosis) einkennist af skyndilegum húðgosum sem koma fram að meðaltali fimm dögum eftir að meðferð er hafin. Þessi gos eru gröftur, þ.e. lítil rauð hvít eða rauð húðgos sem innihalda skýjað eða purulent efni (gröftur). Húðskemmdirnar ganga venjulega yfir innan 1–3 daga frá því að hætt er að nota skaðleg lyf.
☆ Í niðurstöðum Stiftung Warentest 2022 frá Þýskalandi var ánægja neytenda með ModelDerm aðeins minni en með greiddum fjarlækningaráðgjöfum.
Útbreidd sár með roða og graftum koma skyndilega fram.
References
Acute generalized exanthematous pustulosis (AGEP) er húðviðbragð sem einkennist af litlum, gröftfylltum hnúðum á rauðum húðbotni. Það gerist venjulega þegar einhver tekur ákveðin lyf, eins og sýklalyf, og dreifist fljótt um líkamann. Eftir að lyfið sem kallar á er hætt hverfa einkennin venjulega innan tveggja vikna og skilja oft eftir sig einhverja húð. Þó að það sé venjulega ekki alvarlegt og takmarkað við húðina, geta alvarleg tilvik verið flokkuð ásamt öðrum alvarlegum húðviðbrögðum eins og Stevens-Johnson syndrome eða toxic epidermal necrolysis. Meðferð er fyrst og fremst stuðningsmeðferð og horfur fyrir algjöra lausn sjúkdómsins eru yfirleitt frábærar.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
76 ára karlmaður kom á bráðamóttöku þar sem húð hans hafði breyst undanfarna tvo daga. Læknar fundu rauða bletti og upphækkuð svæði á bol hans og handleggjum og fótleggjum. Eftir því sem tíminn leið sameinuðust þessir blettir og hann fékk bólur eins og bólur á rauðu svæðin. Próf sýndu háa fjölda hvítra blóðkorna með mörgum af gerðinni sem kallast daufkyrninga og aukið magn C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
