Panniculitis
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Berklar eru ein mikilvægasta orsökin.
References
Erythema nodosum is the most common form of panniculitis and is characterized by tender erythematous nodules mainly in the lower limbs on the pretibial area. The exact cause of erythema nodosum is unknown, although it appears to be a hypersensitivity response to a variety of antigenic stimuli. Although the etiology is mostly idiopathic, ruling out an underlying disease is imperative before diagnosing primary erythema nodosum. Erythema nodosum can be the first sign of a systemic disease that is triggered by a large group of processes, such as infections, inflammatory diseases, neoplasia, and/or drugs. The most common identifiable causes are streptococcal infections, primary tuberculosis, sarcoidosis, Behçet disease, inflammatory bowel disease, drugs, and pregnancy.
Panniculitis mynda ólíkan hóp bólgusjúkdóma sem taka til fituvef undir húð. Þessar truflanir eru sjaldgæfar hjá börnum. Panniculitis getur verið aðalferlið í kerfislægri röskun eða aukaferli sem stafar af sýkingu, áverka eða útsetningu fyrir lyfjum. Flestar tegundir af brisbólgu hafa sömu klíníska framsetningu (óháð orsökum) , með viðkvæmum, rauðum hnúðum undir húð.
Panniculitides form a heterogenous group of inflammatory diseases that involve the subcutaneous adipose tissue. These disorders are rare in children and have many aetiologies. As in adults, the panniculitis can be the primary process in a systemic disorder or a secondary process that results from infection, trauma or exposure to medication. Some types of panniculitis are seen more commonly or exclusively in children, and several new entities have been described in recent years. Most types of panniculitis have the same clinical presentation (regardless of the aetiology), with tender, erythematous subcutaneous nodules.
Panniculitides form a heterogenous group of inflammatory diseases that involve the subcutaneous adipose tissue. These disorders are rare in children and have many aetiologies. As in adults, the panniculitis can be the primary process in a systemic disorder or a secondary process that results from infection, trauma or exposure to medication. Some types of panniculitis are seen more commonly or exclusively in children, and several new entities have been described in recent years. Most types of panniculitis have the same clinical presentation (regardless of the aetiology), with tender, erythematous subcutaneous nodules.
Panniculitis , bólga í fitu undir húð, kemur venjulega fram með bólguhnútum. Erythema nodosum (EN) er klínískt algengasta form hálsbólgu. Þó að allt að 55% af EN séu talin sjálfvakin, eru algengustu orsakirnar sýkingar, lyf, almennir sjúkdómar eins og sarklíki og bólgusjúkdómar í þörmum, meðgöngu og illkynja sjúkdóma. EN kemur venjulega fram á tánings- og tvítugsaldri og sést oftar hjá konum. Á undan henni kemur oft ósérhæft frumkvæði sem tekur eina til þrjár vikur, sem getur falið í sér hita, vanlíðan og einkenni sýkingar í efri öndunarvegi. Húðskemmdir fylgja síðan, venjulega staðbundnar á teygjuhluta útlima. Sársverkin eru sársaukafull ávöl eða sporöskjulaga, örlítið upphækkuð, rauðir hnúðar sem ekki eru sár. Nákvæm meingerð EN er ekki skilin, en talið er að það stafi af útfellingu ónæmisfléttna í bláæðum skilvegganna í fitu undir húð, sem veldur daufkyrningabólgu. Jafnvel án sérstakrar meðferðar við orsakasjúkdómi leysist EN án meðferðar í flestum tilfellum.
Panniculitis, inflammation of the subcutaneous fat, usually presents with inflammatory nodules. Erythema nodosum (EN) is clinically the most frequent form of panniculitis. Whilst up to 55% of EN is considered idiopathic, the most common causes include infections, drugs, systemic illnesses such as sarcoidosis and inflammatory bowel disease, pregnancy, and malignancy. EN typically presents in the teens and 20s, and is seen more commonly in females. It is often preceded by a non-specific prodrome of one to three weeks, which may include fever, malaise, and symptoms of an upper respiratory tract infection. Cutaneous lesions then follow, typically localized on the extensor aspect of the limbs. The lesions are painful rounded or oval, slightly raised, non-ulcerative red nodules. The exact pathogenesis of EN is not understood, although is thought to result from deposition of immune complexes in the venules of the septae in subcutaneous fat, causing a neutrophilic panniculitis. Even without specific therapy for a causative condition, EN resolves without treatment in most cases.
Panniculitis, inflammation of the subcutaneous fat, usually presents with inflammatory nodules. Erythema nodosum (EN) is clinically the most frequent form of panniculitis. Whilst up to 55% of EN is considered idiopathic, the most common causes include infections, drugs, systemic illnesses such as sarcoidosis and inflammatory bowel disease, pregnancy, and malignancy. EN typically presents in the teens and 20s, and is seen more commonly in females. It is often preceded by a non-specific prodrome of one to three weeks, which may include fever, malaise, and symptoms of an upper respiratory tract infection. Cutaneous lesions then follow, typically localized on the extensor aspect of the limbs. The lesions are painful rounded or oval, slightly raised, non-ulcerative red nodules. The exact pathogenesis of EN is not understood, although is thought to result from deposition of immune complexes in the venules of the septae in subcutaneous fat, causing a neutrophilic panniculitis. Even without specific therapy for a causative condition, EN resolves without treatment in most cases.
„Róðaroði“ er tegund panniculitis sem einkennist af viðkvæmum rauðum hnúðum, 1–10 cm, sem tengjast almennum einkennum þar á meðal hita, vanlíðan og liðverkjum. Hnúðar geta minnkað á 2-6 vikum án þess að mynda sár eða ör. Erythema nodosum tengist sýkingum, þar á meðal lifrarbólgu C, EBV og berklum, meðgöngu, Non-Hodgkin eitilæxli og krabbameini í brisi.