Prurigo nodularis
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References
Prurigo nodularis er langvarandi húðsjúkdómur sem einkennist af mörgum stífum höggum og hnúðum, venjulega að finna á ytri hlutum handleggja og fóta. Þessir hnúðar geta verið mismunandi á litinn frá holdlitnum yfir í bleika og eru mjög klæjar. Þeir geta haft áhrif á fólk á öllum aldri og eru oft tengd öðrum húðsjúkdómum sem valda langvarandi kláða, eins og ofnæmishúðbólgu. Meðferðarmöguleikar eru sterk kláðastillandi lyf, lyf sem hafa áhrif á ónæmiskerfið og lyf sem beinast að taugakerfinu. Meðhöndlun prurigo nodularis felur venjulega í sér langtímameðferð.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Meðferð felur venjulega í sér að nota krem eða sprautur með sterum á viðkomandi svæði. Í alvarlegri eða þrjóskari tilfellum gæti verið þörf á meðferðum eins og ljósameðferð eða lyfjum sem bæla ónæmiskerfið. Thalidomide og lenalidomide eru valkostir fyrir alvarleg tilvik, en þau geta haft alvarlegar aukaverkanir. Nýrri meðferðir (opioid receptor antagonists, neurokinin-1 receptor antagonists) sýna loforð við meðferð prurigo nodularis með færri aukaverkunum samanborið við thalidomide eða lenalidomide.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Chronic prurigo er húðsjúkdómur sem einkennist af langvarandi kláða (varir í meira en 6 vikur) , klóratengdum húðskemmdum og sögu um oft klóra. Það felur í sér taugabólgu og bandvef í húðinni.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Prurigo nodularis er langvarandi húðvandamál sem einkennist af kláðahnútum. Við vitum ekki nákvæmlega hvað veldur því, en svo virðist sem ónæmis- og taugavandamál gegni hlutverki í kláða-klórhringnum. Eins og er, eru engar meðferðir samþykktar af bandaríska FDA sérstaklega fyrir prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
○ Meðferð ― OTC lyf
Að þvo sápusvæðið með sápu hjálpar ekki neitt og getur gert það verra. OTC sterasmyrsl geta hjálpað til við að létta einkennin, en venjulega þarf að nota þau í nokkrar vikur til að lagast. Að halda áfram að taka andhistamín hjálpar einnig til við að létta kláðann.
#OTC steroid ointment
#OTC antihistamine
○ Meðferð
#Intralesional triamcinolone injection