Syphilis - Sárasótt
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Chancres ― aðal sárasýkingar með Treponema pallidum
References
Sárasótt er kynsjúkdómur sem orsakast af bakteríunni Treponema pallidum. Í þessari rannsókn einblínum við á 57 sjúklinga á aldrinum 18-68 ára með seinni sárasótt.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
Sárasótt er bakteríusýking af völdum Treponema pallidum. Það getur líkt eftir ýmsum sjúkdómum og fengið það gælunafnið great imitator. Sárasótt hefur enn áhrif á milljónir á heimsvísu en hægt er að meðhöndla hana á áhrifaríkan hátt með pensilíni.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Treponema pallidum veldur sárasótt með kynferðislegri snertingu eða frá móður til barns á meðgöngu. Jafnvel þó að það séu til einföld próf til að greina það og meðferð með einu langverkandi pensilínsprautu virki vel, þá er sárasótt aftur að verða stórt vandamál um allan heim. Þetta á sérstaklega við meðal karla sem stunda kynlíf með körlum (MSM) í löndum með háar og meðaltekjur. Þó að sum lágtekjulönd hafi náð markmiðum WHO um að koma í veg fyrir að sárasótt berist frá móður til barns, þá er áhyggjuefni aukning á sárasótt meðal HIV-jákvæðra MSM.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
(1) Stækkuð lifur: Þetta finnst oft og getur gerst samhliða stækkuðu milta. Skoðun á lifrarsýni í myrkvasviðssmásjá getur leitt í ljós að spirochete sé til staðar. Lifrarpróf geta sýnt frávik. (2) Gulnun á húðinni (gula) : Hvort einhver sýnir gulu fer eftir því hversu mikið lifrin er fyrir áhrifum. (3) Nefrennsli: Oft eitt af fyrstu einkennunum, venjulega innan fyrstu viku eftir fæðingu. (4) Bólgnir eitlar: Almenn bólga í eitlum, venjulega sársaukalaus, er einnig algeng. (5) Húðútbrot: Útbrot birtast venjulega einni til tveimur vikum eftir nefrennsli. Þú gætir séð litla rauða eða bleika bletti á baki, rassi, læri og iljum. Þessi útbrot geta þróast yfir í flögnun og skorpu.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
○ Greining og meðferð
VDRL og RPR er hægt að nota til að staðfesta nýlega sýkingu og skima fyrir sárasótt. FTA-ABS próf er sértækara próf og hægt að nota til að athuga fyrri sýkingarsögu. Penicillín er notað til að meðhöndla sárasótt.