Angiofibroma
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References
Cutaneous angiofibromas può comparire in varie parti del corpo. Sul viso sono spesso conosciuti come papule fibrose o adenoma sebaceo; sul pene si chiamano pearly penile papules ; sotto l'unghia sono chiamati angiofibromi periungueali o tumori di Koenen; e in bocca vengono chiamati fibromi orali. Gli angiofibromi facciali sono una caratteristica importante di tuberous sclerosis (TS) , una malattia ereditaria che colpisce la pelle, i reni, il cuore, il cervello e i polmoni. Si sviluppano tipicamente sul viso durante l'infanzia o la prima età adulta nei soggetti affetti da TS. Avere tre o più angiofibromi facciali o due o più angiofibromi periungueali è considerato significativo nella diagnosi di TS. Inoltre, possono essere presenti angiofibromi facciali multipli nelle condizioni (multiple endocrine neoplasia type 1 (MEN-1) e Birt-Hogg-Dubé syndrome) . Pearly penile papules si trovano lungo il margine coronale e il solco del pene. Sono protuberanze persistenti e indolori più comunemente osservate negli uomini non circoncisi.
Cutaneous angiofibromas can be located on different areas of the body including the face where they are commonly called fibrous papules or adenoma sebaceum on the penis where they are called pearly penile papules, underneath the nail where they are called periungual angiofibromas or Koenen tumors, and in the mouth where they are called oral fibromas. Facial angiofibromas are considered one of the most obvious clinical presentations of tuberous sclerosis (TS), an autosomal dominant hamartomatous disorder that affects the skin, kidneys, heart, brain, and lungs. With TS, angiofibromas typically arise on the face in childhood and early adulthood. Both facial angiofibromas (greater than or equal to 3 needed) and periungual angiofibroma (greater than or equal to 2 needed) are 2 of the major criteria for TS. Multiple facial angiofibromas are also found in multiple endocrine neoplasia type 1 (MEN-1) and Birt-Hogg-Dube syndrome. Pearly penile papules are chronic, asymptomatic, papules found on the coronal margin and sulcus of the penis. They are more common in uncircumcised men.
Cutaneous angiofibromas can be located on different areas of the body including the face where they are commonly called fibrous papules or adenoma sebaceum on the penis where they are called pearly penile papules, underneath the nail where they are called periungual angiofibromas or Koenen tumors, and in the mouth where they are called oral fibromas. Facial angiofibromas are considered one of the most obvious clinical presentations of tuberous sclerosis (TS), an autosomal dominant hamartomatous disorder that affects the skin, kidneys, heart, brain, and lungs. With TS, angiofibromas typically arise on the face in childhood and early adulthood. Both facial angiofibromas (greater than or equal to 3 needed) and periungual angiofibroma (greater than or equal to 2 needed) are 2 of the major criteria for TS. Multiple facial angiofibromas are also found in multiple endocrine neoplasia type 1 (MEN-1) and Birt-Hogg-Dube syndrome. Pearly penile papules are chronic, asymptomatic, papules found on the coronal margin and sulcus of the penis. They are more common in uncircumcised men.
1) faccia
Fibrous papule
2) pene
Pearly penile papule
3) sotto l'unghia della mano o del piede
Periungual angiofibroma