Squamous cell carcinoma - Carcinoma A Cellule Squamose
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Squamous cell carcinoma well differentiated ― Si osserva una cheratosi attinica adiacente.
References
Squamous cell carcinoma (SCC) è il secondo tumore della pelle più comune negli Stati Uniti, dopo basal cell carcinoma. Di solito inizia da lesioni precancerose chiamate actinic keratosis e può diffondersi ad altre parti del corpo. La causa principale è l’esposizione alle radiazioni ultraviolette (UV) del sole, che si accumulano nel tempo. Il trattamento di solito prevede la rimozione chirurgica, soprattutto per il SCC sulla testa e sul collo. La radioterapia è un'opzione per i pazienti anziani o per coloro che non possono sottoporsi a un intervento chirurgico. L’immunosoppressione aumenta il rischio di SCC. Anche se raro, l’SCC può diffondersi, soprattutto nei pazienti con sistema immunitario indebolito. Controlli regolari e protezione solare sono importanti per chi soffre di SCC.
Squamous cell carcinoma of the skin or cutaneous squamous cell carcinoma is the second most common form of skin cancer in the United States, behind basal cell carcinoma. Squamous cell carcinoma has precursor lesions called actinic keratosis, exhibits tumor progression and has the potential to metastasize in the body. Ultraviolet (UV) solar radiation is the primary risk factor in the development of cutaneous squamous cell carcinoma and the cumulative exposure received over a lifetime plays a major part in the development of this cancer. Surgical excision is the primary treatment modality for cutaneous squamous cell carcinoma, with Mohs micrographic surgery being the preferred excisional technique for squamous cell carcinoma of the head and neck, and in other areas of high risk or squamous cell carcinoma with high-risk characteristics. Radiation therapy is reserved for squamous cell carcinoma in older patients or those who will not tolerate surgery, or when it has not been possible to obtain clear margins surgically. Adjuvant radiotherapy is commonly after surgical treatment in very high tumors. Immunosuppression significantly increases the risk of squamous cell carcinoma over the course of an individual’s life. Metastasis is uncommon for squamous cell carcinomas arising in areas of chronic sun exposure, but it can take place, and the risk is increased in immunosuppressed patients. Patients with cutaneous squamous cell carcinoma should be examined regularly and remember to use measures to protect from UV damage.
Squamous cell carcinoma of the skin or cutaneous squamous cell carcinoma is the second most common form of skin cancer in the United States, behind basal cell carcinoma. Squamous cell carcinoma has precursor lesions called actinic keratosis, exhibits tumor progression and has the potential to metastasize in the body. Ultraviolet (UV) solar radiation is the primary risk factor in the development of cutaneous squamous cell carcinoma and the cumulative exposure received over a lifetime plays a major part in the development of this cancer. Surgical excision is the primary treatment modality for cutaneous squamous cell carcinoma, with Mohs micrographic surgery being the preferred excisional technique for squamous cell carcinoma of the head and neck, and in other areas of high risk or squamous cell carcinoma with high-risk characteristics. Radiation therapy is reserved for squamous cell carcinoma in older patients or those who will not tolerate surgery, or when it has not been possible to obtain clear margins surgically. Adjuvant radiotherapy is commonly after surgical treatment in very high tumors. Immunosuppression significantly increases the risk of squamous cell carcinoma over the course of an individual’s life. Metastasis is uncommon for squamous cell carcinomas arising in areas of chronic sun exposure, but it can take place, and the risk is increased in immunosuppressed patients. Patients with cutaneous squamous cell carcinoma should be examined regularly and remember to use measures to protect from UV damage.
Cutaneous squamous cell carcinoma (CSCC) è il secondo tumore più comune tra gli esseri umani e il suo numero è in aumento. Sebbene il CSCC mostri solitamente un comportamento clinico benigno, può diffondersi sia localmente che ad altre parti del corpo. Gli scienziati hanno identificato percorsi specifici coinvolti nello sviluppo del CSCC, che portano a nuovi trattamenti. L’elevato numero di mutazioni e l’aumento del rischio nei pazienti immunodepressi hanno spinto allo sviluppo dell’immunoterapia. Questa recensione esamina le radici genetiche del CSCC e gli ultimi trattamenti mirati a molecole specifiche e al sistema immunitario.
Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans and its incidence continues to rise. Although CSCC usually display a benign clinical behavior, it can be both locally invasive and metastatic. The signaling pathways involved in CSCC development have given rise to targetable molecules in recent decades. In addition, the high mutational burden and increased risk of CSCC in patients under immunosuppression were part of the rationale for developing the immunotherapy for CSCC that has changed the therapeutic landscape. This review focuses on the molecular basis of CSCC and the current biology-based approaches of targeted therapies and immune checkpoint inhibitors
Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans and its incidence continues to rise. Although CSCC usually display a benign clinical behavior, it can be both locally invasive and metastatic. The signaling pathways involved in CSCC development have given rise to targetable molecules in recent decades. In addition, the high mutational burden and increased risk of CSCC in patients under immunosuppression were part of the rationale for developing the immunotherapy for CSCC that has changed the therapeutic landscape. This review focuses on the molecular basis of CSCC and the current biology-based approaches of targeted therapies and immune checkpoint inhibitors
○ Diagnosi e trattamento
#Dermoscopy
#Skin biopsy