Livedoid vasculitis
Livedoid vasculitis היא מחלה עורית כרונית הנראית בעיקר אצל נשים צעירות עד גיל העמידה. ראשי תיבות אחד המשמשים לתיאור תכונותיו הוא "כיבים פורפוריים כואבים עם דפוס רשתי של הגפיים התחתונות" (PURPLE). זה קשור למספר מחלות, כולל יתר לחץ דם ורידי כרוני ודליות.
☆ בתוצאות 2022 של Stiftung Warentest מגרמניה, שביעות הרצון של הצרכנים מ-ModelDerm הייתה נמוכה רק במעט בהשוואה לייעוץ טלרפואי בתשלום.
זה יכול להיות מלווה בכאב.
References
Livedoid vasculopathy הוא מצב עור נדיר המאופיין בכיבים כואבים שחוזרים כל הזמן ברגליים התחתונות.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy הוא מצב עור נדיר הגורם לכיבים חוזרים ברגליים התחתונות, ומשאיר מאחוריהם צלקות חיוורות הידועות בשם atrophie blanche. למרות שהסיבה המדויקת עדיין לא ברורה, מאמינים שקרישת דם מוגברת (hypercoagulability) היא הגורם העיקרי, כאשר הדלקת משחקת תפקיד משני. גורמים התורמים לקרישה כוללים כדלקמן - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. בביופסיות, המצב מראה קרישי דם בתוך כלי הדם, התעבות של דפנות כלי הדם וצלקות. הטיפול כולל גישה רב-שכבתית המתמקדת במניעת קרישי דם באמצעות תרופות כמו תרופות נגד טסיות, מדללי דם וטיפול פיברינוליטי. ניתן להשתמש בתרופות שונות למצב עור זה - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy הוא מצב נדיר שבו מתרחשים נגעים בשתי הרגליים. היווצרות קרישי דם בכלי דם זעירים נחשבת נגרמת על ידי קרישה מוגברת ופירוק קריש מופחת, יחד עם נזק לרירית כלי הדם. זה שכיח יותר אצל נשים, במיוחד בין הגילאים 15 עד 50. הפסקת עישון, טיפול בפצעים ושימוש בתרופות כמו מדללי דם ותרופות נוגדות טסיות היו יעילים.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
