Acanthosis nigricans - 黒色表皮腫
肥満の人によく見られます。
relevance score : -100.0%
ReferencesAcanthosis nigricans は、基礎疾患の皮膚症状です。多くの場合、首、脇の下、鼠径部などの皮膚のひだに発生し、境界が不明瞭なビロードのような黒い斑点のように見えます。この状態は通常、糖尿病 (diabetes mellitus) やインスリン抵抗性 (insulin resistance) に関連していますが、まれに体内のがん (cancer) を示している可能性があります。また、ホルモンの問題や、ステロイド (systemic glucocorticoids) や経口避妊薬 (oral contraceptives) などの特定の薬の服用によって症状が現れることもあります。
Acanthosis nigricans is a cutaneous manifestation of an underlying condition. It usually develops in skin folds, such as the back of the neck, axilla, and groin, where it presents as velvety hyper-pigmented patches with poorly defined borders. Acanthosis nigricans is most commonly associated with diabetes and insulin resistance, but rarely it can be a sign of internal malignancy. It can also occur with hormone disorders or with the use of certain medications like systemic glucocorticoids and oral contraceptives.
Acanthosis nigricans is a cutaneous manifestation of an underlying condition. It usually develops in skin folds, such as the back of the neck, axilla, and groin, where it presents as velvety hyper-pigmented patches with poorly defined borders. Acanthosis nigricans is most commonly associated with diabetes and insulin resistance, but rarely it can be a sign of internal malignancy. It can also occur with hormone disorders or with the use of certain medications like systemic glucocorticoids and oral contraceptives.
Acanthosis nigricans (AN) は、インスリン抵抗性、糖尿病、肥満、内部悪性腫瘍、ホルモンの問題、薬への反応など、さまざまな健康上の問題に関連する一般的な皮膚疾患です。 AN の治療では、根本的な健康上の問題に対処することに重点を置きます。まず医師は、肥満、高コレステロール、高血圧、2 型糖尿病などのインスリン抵抗性症候群の兆候がないかどうかを検査します。医師は多くの場合、皮膚の肥厚を抑える治療法の第一選択として外用レチノイド (topical retinoids) を処方します。ただし、肌の黒ずみに完全に対処できるわけではありません。サリチル酸 (salicylic acid)、ポドフィリン (podophyllin)、尿素 (urea)、カルシポトリオール (calcipotriol) のような他の治療オプションも頻繁に適用する必要があります。
Acanthosis nigricans (AN) is a common dermatologic manifestation of systemic disease that is associated with insulin resistance, diabetes mellitus, obesity, internal malignancy, endocrine disorders, and drug reactions. Treatment of AN primarily focuses on resolution of the underlying disease processes causing the velvety, hyperpigmented, hyperkeratotic plaques found on the skin. Initial considerations for the AN workup include evaluating patients for insulin resistance syndrome characterized by obesity, dyslipidemia, hypertension, and diabetes mellitus type II. For cosmetic treatment, topical retinoids are considered the first-line therapy for insulin-resistant AN by modifying keratinization rate. However, topical tretinoin requires application for long durations and improves hyperkeratosis, but not hyperpigmentation. Topical salicylic acid, podophyllin, urea, and calcipotriol also require frequent application, while TCA peels may provide a faster and less time-intense burden.
Acanthosis nigricans (AN) is a common dermatologic manifestation of systemic disease that is associated with insulin resistance, diabetes mellitus, obesity, internal malignancy, endocrine disorders, and drug reactions. Treatment of AN primarily focuses on resolution of the underlying disease processes causing the velvety, hyperpigmented, hyperkeratotic plaques found on the skin. Initial considerations for the AN workup include evaluating patients for insulin resistance syndrome characterized by obesity, dyslipidemia, hypertension, and diabetes mellitus type II. For cosmetic treatment, topical retinoids are considered the first-line therapy for insulin-resistant AN by modifying keratinization rate. However, topical tretinoin requires application for long durations and improves hyperkeratosis, but not hyperpigmentation. Topical salicylic acid, podophyllin, urea, and calcipotriol also require frequent application, while TCA peels may provide a faster and less time-intense burden.
○ 原因
通常、40歳未満の人に発生し、遺伝性の可能性があり、肥満や甲状腺機能低下症、先端肥大症 (acromegaly)、多嚢胞性卵巣疾患、インスリン抵抗性糖尿病、クッシング病などの内分泌疾患と関連している可能性があります。
○ 治療 ― OTC医薬品
#40% urea cream