Amyloidosis - アミロイドーシス
amyloidosis cutis dyschromica の皮膚の特徴 ― (A) 下腿の色素沈着過剰および色素沈着低下の斑
References
26歳の女性が、10年来の足のかゆみを訴えて来院されました。ステロイドクリームやタザロテンクリームを使用したにもかかわらず、発疹は改善しませんでした。彼女には関連する家族歴はありませんでした。私たちが彼女を検査したところ、彼女の脚の前部に盛り上がった荒れた斑点が見つかりました。これは lichen amyloidosis と呼ばれる病気と一致しました。
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
Lichen Amyloidosis は、原因不明の持続的なかゆみを伴う稀な皮膚疾患です。通常、皮膚の外表面に隆起した変色した斑点の塊として現れます。 Lichen Amyloidosis は通常 50 ～ 60 歳の人に発生しますが、残念ながら治療法はありません。現在利用可能な治療法は通常、うまく機能しません。
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen amyloidosis は、長期にわたるかゆみを伴う皮膚の状態です。主に背中、すね、太もも、腕に見られる肥厚した隆起の塊で知られています。顕微鏡で検査すると、 Lichen amyloidosis は皮膚の外層の肥厚および拡大とともに皮膚の最上層にアミロイドが蓄積していることを示します。 Lichen amyloidosis の正確な原因はまだ完全には理解されていませんが、これまでの研究では、皮膚のこすれや摩擦、細胞死、ウイルス感染などの要因と関連付けられています。 Lichen amyloidosis は、 atopic dermatitis, lichen planus, and mycosis fungoides などの他のいくつかの皮膚疾患と関連しているようです。
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
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#Electrophoresis of blood or urine
#Skin biopsy