Angiofibroma - 血管線維腫
References
Cutaneous angiofibromas は体のさまざまな部分に現れる可能性があります。顔の場合は、線維性丘疹または皮脂腺腫としてよく知られています。ペニスでは pearly penile papules と呼ばれます。爪の下にあるものは爪周囲血管線維腫またはケーネン腫瘍と呼ばれます。口の中では口腔線維腫と呼ばれます。顔面血管線維腫は、皮膚、腎臓、心臓、脳、肺に影響を及ぼす遺伝性疾患である tuberous sclerosis (TS) の顕著な特徴です。これらは通常、TS患者の小児期または成人初期に顔に発生します。 3 つ以上の顔面血管線維腫または 2 つ以上の爪周囲血管線維腫があることは、TS の診断において重要であると考えられます。さらに、症状 (multiple endocrine neoplasia type 1 (MEN-1) および Birt-Hogg-Dubé syndrome) では、複数の顔面血管線維腫が存在する場合があります。 Pearly penile papules は、陰茎の冠状縁と溝に沿って見られます。これらは、割礼を受けていない男性によく見られる、持続性の痛みのない隆起です。
Cutaneous angiofibromas can be located on different areas of the body including the face where they are commonly called fibrous papules or adenoma sebaceum on the penis where they are called pearly penile papules, underneath the nail where they are called periungual angiofibromas or Koenen tumors, and in the mouth where they are called oral fibromas. Facial angiofibromas are considered one of the most obvious clinical presentations of tuberous sclerosis (TS), an autosomal dominant hamartomatous disorder that affects the skin, kidneys, heart, brain, and lungs. With TS, angiofibromas typically arise on the face in childhood and early adulthood. Both facial angiofibromas (greater than or equal to 3 needed) and periungual angiofibroma (greater than or equal to 2 needed) are 2 of the major criteria for TS. Multiple facial angiofibromas are also found in multiple endocrine neoplasia type 1 (MEN-1) and Birt-Hogg-Dube syndrome. Pearly penile papules are chronic, asymptomatic, papules found on the coronal margin and sulcus of the penis. They are more common in uncircumcised men.
Cutaneous angiofibromas can be located on different areas of the body including the face where they are commonly called fibrous papules or adenoma sebaceum on the penis where they are called pearly penile papules, underneath the nail where they are called periungual angiofibromas or Koenen tumors, and in the mouth where they are called oral fibromas. Facial angiofibromas are considered one of the most obvious clinical presentations of tuberous sclerosis (TS), an autosomal dominant hamartomatous disorder that affects the skin, kidneys, heart, brain, and lungs. With TS, angiofibromas typically arise on the face in childhood and early adulthood. Both facial angiofibromas (greater than or equal to 3 needed) and periungual angiofibroma (greater than or equal to 2 needed) are 2 of the major criteria for TS. Multiple facial angiofibromas are also found in multiple endocrine neoplasia type 1 (MEN-1) and Birt-Hogg-Dube syndrome. Pearly penile papules are chronic, asymptomatic, papules found on the coronal margin and sulcus of the penis. They are more common in uncircumcised men.
1) 顔
Fibrous papule
2) ペニス
Pearly penile papule
3) 手の爪または足の爪の下
Periungual angiofibroma