Acute generalized exanthematous pustulosis - Pustulosis Exanthematous Generalisata Akut
Pustulosis Exanthematous Generalisata Akut (Acute generalized exanthematous pustulosis) (AGEP) minangka reaksi kulit langka sing ing 90 % kasus ana hubungane karo panggunaan obat. Pustulosis exanthematous generalisata akut (acute generalized exanthematous pustulosis) ditandhani dening erupsi kulit dadakan sing biasane muncul rata‑rata limang dina sawisé pangobatan diwiwiti. Jeblugan iki wujud pustula, yaiku erupsi cilik abang putih utawa abang ing kulit sing ngandhut bahan cair utawa purulen (nanah). Lesi kulit biasane ilang sajrone 1–3 dina sawisé mandhegake obat sing nyebabake.
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relevance score : -100.0%
ReferencesAcute generalized exanthematous pustulosis (AGEP) yaiku reaksi kulit sing ditandhani dening benjolan cilik kebak nanah ing kulit abang. Biasane muncul nalika seseorang nggunakake obat-obatan tartamtu, kayata antibiotik, lan cepet nyebar ing awak. Sawisé mandhegake obat sing nyebabake, gejala kasebut umume ilang sajrone rong minggu lan asring ninggalake kulit sing kering. Sanadyan umume ora serius lan winates ing kulit, kasus sing abot bisa diklasifikasikake bebarengan karo reaksi kulit serius liyane kaya Stevens‑Johnson syndrome utawa toxic epidermal necrolysis. Perawatan utama yaiku perawatan suportif, lan prognosis kanggo resolusi lengkap penyakit iki biasane apik banget.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
Wong lanang umur 76 taun teka ing kamar darurat amarga kulite wis owah sajrone rong dina kepungkur. Dokter nemokake bintik-bintik abang lan area sing diangkat ing batang lan tangan lan sikil. Suwe-suwe, bintik-bintik iki gabung, lan dheweke ngalami benjolan kaya jerawat ing wilayah abang. Tes nuduhake jumlah sel getih putih sing dhuwur kanthi akeh jinis sing diarani neutrofil, lan tingkat tambah C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
