Dysplastic nevus - Nevus Displastik
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Dysplastic nevi ― Biopsi dianjurake kanggo wong Kulon.
References
Dysplastic nevus , uga dikenal minangka atypical utawa Clarks nevus, wis nyebabake debat ing dermatologi lan dermatopatologi. Dokter asring biopsi moles iki amarga bisa katon ora normal lan nambah keprihatinan babagan melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
Dysplastic nevi , uga dikenal minangka atipikal utawa Clark nevi, kadhangkala bisa nyebabake melanoma. Udakara 36% melanoma ditemokake ing cedhak nevi dysplastic. Tandha yen nevus dysplastic bisa dadi melanoma kalebu wangun sing ora rata, owah-owahan pigmen luwih akeh, utawa werna abu-abu. Kanker iki biasane kedadeyan ing umur sing luwih enom (sekitar pertengahan telung puluhan) , bisa dadi pirang-pirang, lan asring ana ing batang. Secara genetis, dysplastic nevi ana ing antarane nevi jinak lan melanoma. Nanging, mung 20% nganti 30% melanoma sing asale saka nevi sing ana. Amarga umume nevi ora dadi melanoma, biasane ora dianjurake kanggo mbusak kanthi nyegah.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Melanoma minangka jinis tumor sing dibentuk nalika melanosit, sel sing tanggung jawab kanggo warna kulit, dadi kanker. Melanosit asalé saka puncak saraf. Iki tegese melanoma bisa berkembang ora mung ing kulit nanging uga ing wilayah liyane ing ngendi sel-sel puncak saraf migrasi, kayata saluran pencernaan lan otak. Tingkat kelangsungan hidup kanggo pasien melanoma tahap awal (tahap 0) dhuwur ing 97%, dene mudhun kanthi signifikan nganti udakara 10% kanggo wong sing didiagnosis penyakit tahap lanjut (tahap IV) .
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
○ Risiko Kanker
Kaya sing katon ing wong Kaukasia ing Amerika Serikat, sing duwe nevi dysplastic duwe risiko seumur hidup kanggo ngembangake melanoma luwih saka 10%. Ing sisih liya, sing ora duwe nevus dysplastic duwe risiko ngembangake melanoma kurang saka 1%.
○ Pencegahan kanggo wong sing duwe nevi displastik
Pemeriksaan diri kulit biasane dianjurake kanggo nyegah melanoma (kanthi ngenali nevi atipikal sing bisa dicopot) utawa kanggo deteksi awal tumor sing ana. Wong sing duwe riwayat kanker kulit pribadi utawa kulawarga utawa macem-macem nevi atipikal kudu ndeleng dokter kulit paling ora setaun sepisan kanggo mesthekake yen dheweke ora ngalami melanoma.
Singkatan [ABCDE] wis migunani kanggo mbantu panyedhiya perawatan kesehatan lan wong awam ngelingi karakteristik utama melanoma. Sayange kanggo wong rata-rata, akeh keratosis seborrheic, sawetara lentigo senilis, lan malah warts bisa duwe ciri [ABCDE], lan ora bisa dibedakake saka melanoma.
○ [ABCDE]
Asymmetrical: Lesi kulit asimetris.
Border: Wates lesi ora teratur.
Color: melanoma biasane duwe pirang-pirang warna sing ora teratur.
Diameter: nevi sing luwih gedhe tinimbang 6 mm luwih cenderung dadi melanoma tinimbang nevi sing luwih cilik.
Evolution: Evolusi (yaiku owah-owahan) saka nevus utawa lesi bisa nuduhake yen lesi kasebut dadi ganas.