Juvenile xanthogranuloma - Xanthogranuloma Remaja
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ReferencesJuvenile xanthogranuloma (JXG) minangka kondisi sing cukup umum lan jinis non‑Langerhans cell histiocytic disorder sing paling umum ing bocah‑bocah. Ing udakara 75 % kasus, lesi kasebut katon ing taun pisanan urip, lan luwih saka 15‑20 % pasien ngalami wiwit lair. Nalika langka ing wong diwasa, JXG biasane paling asring ditemokake ing wong umur pungkasan rong puluhan nganti telung puluhan, lan paling akeh pasien diwasa mung duwe siji lesi. Secara klinis, lesi katon minangka gumpalan kuning‑oranye‑coklat tunggal utawa pirang‑pirang, utamane ing pasuryan, gulu, lan awak ndhuwur. Lesi ing mulut ora umum, nanging bisa muncul minangka gumpalan kuning ing pinggir ilat utawa ing panggonan liya ing tutuk, lan bisa nyebabake ulkus lan getihen. Lesi kulit biasane ora nyebabake gejala lan cenderung ilang dhewe sajrone pirang‑pirang taun. Sanajan langka, keterlibatan okular minangka komplikasi sing paling umum sawise kulit, diikuti dening keterlibatan paru‑paru. Ocular JXG biasane mung mengaruhi siji mripat lan kedadeyan ing kurang saka 0,5 % pasien, sanajan udakara 40 % pasien sing nandhang keterlibatan okular uga duwe pirang‑pirang lesi kulit nalika didiagnosis.
Juvenile xanthogranuloma (JXG) is a relatively common entity and is the most common form of non-Langerhans cell histiocytic disorder of childhood., It is estimated that in 75% of cases, lesions appear during the first year of life, with >15-20% of patients having lesions at birth. JXG is rare in adults, with a peak incidence in the late twenties to thirties. The majority of adult patients have solitary lesions. Typically, the clinical presentation consists of solitary or multiple yellow-orange-brown firm papules or nodules. The most common locations are the face, neck, and upper torso. Oral lesions are rare and often occur as a yellow nodule on the lateral aspects of the tongue. Oral lesions can also arise on the gingival, buccal mucosa, and midline hard palate and may ulcerate and bleed. Cutaneous lesions are usually asymptomatic, and most lesions spontaneously involute over the course of several years. Although occurring rarely, ocular involvement is the most common extracutaneous site involved, followed by the lungs. Ocular JXG is nearly always unilateral and develops in less than 0.5% of patients. Approximately 40% of patients with ocular JXG, however, have multiple cutaneous lesions at the time of diagnosis.
Juvenile xanthogranuloma (JXG) is a relatively common entity and is the most common form of non-Langerhans cell histiocytic disorder of childhood., It is estimated that in 75% of cases, lesions appear during the first year of life, with >15-20% of patients having lesions at birth. JXG is rare in adults, with a peak incidence in the late twenties to thirties. The majority of adult patients have solitary lesions. Typically, the clinical presentation consists of solitary or multiple yellow-orange-brown firm papules or nodules. The most common locations are the face, neck, and upper torso. Oral lesions are rare and often occur as a yellow nodule on the lateral aspects of the tongue. Oral lesions can also arise on the gingival, buccal mucosa, and midline hard palate and may ulcerate and bleed. Cutaneous lesions are usually asymptomatic, and most lesions spontaneously involute over the course of several years. Although occurring rarely, ocular involvement is the most common extracutaneous site involved, followed by the lungs. Ocular JXG is nearly always unilateral and develops in less than 0.5% of patients. Approximately 40% of patients with ocular JXG, however, have multiple cutaneous lesions at the time of diagnosis.
Juvenile xanthogranulomas (JXGs) ora umum, penyakit jinak sing kalebu ing kategori non‑Langerhans cell histiocytoses sing luwih gedhe. Biasane katon minangka siji utawa luwih gumpalan abang utawa kuning, asring ditemokake ing sirah utawa gulu. Umume JXG berkembang nalika lair utawa ing taun pisanan urip. Sanadyan ora umum, kadhangkala bisa nyebabake keterlibatan wilayah sing ngluwihi kulit, kanthi keterlibatan mata minangka perkara sing kudu diawasi miturut literatur sing ana. Umume, JXG ing kulit ilang dhewe lan biasane ora mbutuhake perawatan.
Juvenile xanthogranulomas (JXGs) are uncommon, benign diseases that are part of a larger category of non-Langerhans cell histiocytoses. They typically show up as one or more red or yellowish lumps, often found on the head or neck. Most JXGs develop either at birth or within the first year of life. While it's unusual, sometimes they can affect areas beyond the skin, with eye involvement being something to watch for according to existing literature. Generally, JXGs on the skin go away on their own and typically don't need treatment.
Juvenile xanthogranulomas (JXGs) are uncommon, benign diseases that are part of a larger category of non-Langerhans cell histiocytoses. They typically show up as one or more red or yellowish lumps, often found on the head or neck. Most JXGs develop either at birth or within the first year of life. While it's unusual, sometimes they can affect areas beyond the skin, with eye involvement being something to watch for according to existing literature. Generally, JXGs on the skin go away on their own and typically don't need treatment.
Lesi okular ditemokaké ing nganti 10 % pasien kanthi JXG lan bisa nyebabaké gangguan penglihatan. Senadyan lesi kulit biasané ilang kanthi spontan, lesi okular arang‑arange mari kanthi spontan lan mbutuhaké perawatan.