Livedoid vasculitis - Vaskulitis Livedoid
Vaskulitis Livedoid (Livedoid vasculitis) minangka penyakit kulit kronis sing umume katon ing wanita enom nganti setengah baya. Siji akronim sing digunakake kanggo njlèntrèhaké fitur kasebut yaiku "ulkus purpura sing nyeri kanthi pola retikuler saka ekstremitas ngisor" (PURPLE). Iki digandhengake karo sawetara penyakit, kalebu hipertensi vena kronis lan varicosities.
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References
Livedoid vasculopathy minangka kondisi kulit langka sing ditondoi dening ulkus nyeri sing terus bali ing sikil ngisor.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy minangka kondisi kulit langka sing nyebabake ulkus ambalan ing sikil ngisor, ninggalake bekas pucet sing dikenal minangka atrophie blanche. Nalika panyebab sing tepat isih durung jelas, dipercaya manawa pembekuan getih mundhak (hypercoagulability) minangka faktor utama, kanthi inflamasi minangka peran sekunder. Faktor sing nyumbang kanggo pembekuan kalebu ing ngisor iki - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. Ing biopsi, kondisi kasebut nuduhake gumpalan getih ing jero pembuluh, penebalan tembok pembuluh, lan jaringan parut. Perawatan kalebu pendekatan multi-cabang fokus kanggo nyegah pembekuan getih kanthi obat-obatan kaya obat anti-trombosit, pengencer getih, lan terapi fibrinolitik. Maneka warna obat bisa digunakake kanggo kondisi kulit iki - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy minangka kondisi langka ing ngendi lesi dumadi ing sikil loro. Pembentukan gumpalan getih ing pembuluh getih cilik dikira disebabake dening pembekuan sing tambah lan nyuda pemecahan beku, bebarengan karo karusakan ing lapisan pembuluh. Iku luwih umum ing wanita, utamane antarane umur 15 lan 50. Mungkasi ngrokok, ngrawat tatu, lan nggunakake obat-obatan kayata pengencer getih lan obat antiplatelet wis efektif.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
