Porokeratosis
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Ing asil Stiftung Warentest 2022 saka Jerman, kepuasan konsumen karo ModelDerm mung luwih murah tinimbang konsultasi telemedicine sing dibayar.
Ing asil Stiftung Warentest 2022 saka Jerman, kepuasan konsumen karo ModelDerm mung luwih murah tinimbang konsultasi telemedicine sing dibayar.
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ReferencesPorokeratosis minangka kondhisi kulit langka sing ditondoi dening masalah keratinisasi, sing nyebabake bintik‑bintik berbentuk cincin utawa benjolan kasar ing kulit. Ciri khas sing bisa dideleng ing mikroskop yaiku anané lamella cornoid, susunan sel khusus ing lapisan ndhuwur kulit. Porokeratosis muncul ing macem‑macem formulir (disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, linear porokeratosis). Wigati dimangerteni manawa porokeratosis bisa malih dadi kanker kulit. Cara paling tepat kanggo diagnosa porokeratosis yaiku kanthi biopsi lesi sing diangkat, sanajan saiki durung ana protokol perawatan standar.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Disseminated superficial actinic porokeratosis (DSAP) yaiku penyakit keratinisasi sing ora teratur. Iki salah siji saka enem jinis porokeratosis, lan biasane mengaruhi wilayah sing luwih luas tinimbang jinis liyane (linear, Mibelli's, punctate, palmoplantar disseminated, superficial porokeratosis). Jinis porokeratosis sing eruptif asring ana hubungane karo kanker, kekebalan sing lemah, utawa inflamasi. Faktor risiko kalebu faktor genetik, penekanan sistem kekebalan, lan paparan cahya srengenge. DSAP diwiwiti minangka lesi berwarna keemasan utawa coklat kanthi pinggiran sing menonjol ing wilayah sing kena srengenge, kadhangkala disertai rasa gatel. Pengobatan beda-beda lan bisa kalebu krim topikal, terapi cahya, utawa obat kaya 5-fluorouracil utawa retinoid. Lesi iki dianggep prakanker, kanthi kemungkinan 7,5‑10 % dadi karsinoma sel skuamosa utawa sel basal.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Wong lanang umur 52 taun, sadurunge sehat, nemokake tembelan rata berbentuk cincin ing ujung driji sikil papat, sing wis ana suwene 2 taun tanpa gejala. Awale muncul minangka benjolan cilik, keras, lan alon-alon nambah ukuran. Sanajan wis nyoba macem‑macem perawatan kaya cryotherapy, krim, antijamur, lan antibiotik, lesi ora nambah. Pemeriksaan dermokopi nuduhake pusat sing garing lan abang kanthi pinggiran sing kandel lan kasar. Biopsi kulit cilik sing dijupuk saka pinggiran tembelan nuduhake proliferasi sel abnormal ing lapisan epidermis, ngukuhaké diagnosis porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
Asring biopsi ditindakake amarga lesi iki bisa katon mirip karo keratosis aktinik utawa karsinoma sel skuamosa.