Porokeratosis
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References
Porokeratosis minangka kondhisi kulit langka sing ditondoi dening masalah keratinisasi, sing nyebabake bintik-bintik sing bentuke cincin utawa benjolan kasar ing kulit. Fitur sing ditemtokake ing mikroskop yaiku anané lamella cornoid, susunan sel sing spesifik ing lapisan ndhuwur kulit. Porokeratosis teka ing macem-macem formulir (disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, linear porokeratosis) . Wigati dimangerteni yen porokeratosis bisa dadi kanker kulit. Cara paling apik kanggo diagnosa porokeratosis yaiku liwat biopsi saka wates sing diangkat, sanajan saiki ora ana protokol perawatan standar.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Disseminated superficial actinic porokeratosis (DSAP) yaiku penyakit keratinisasi sing ora teratur. Iku salah siji saka enem jinis porokeratosis, lan biasane mengaruhi wilayah luwih gedhe dibandhingake liyane (linear, Mibelli's, punctate, palmoplantar disseminated, superficial porokeratosis) . Jenis porokeratosis sing eruptif asring ana hubungane karo kanker, kekebalan lemah, utawa inflamasi. Faktor risiko kalebu genetika, penekanan kekebalan, lan cahya srengenge. DSAP diwiwiti minangka benjolan jambon utawa coklat kanthi pinggiran munggah ing wilayah sing kena srengenge, kadhangkala nyebabake gatal-gatal. Pangobatan beda-beda lan bisa uga kalebu krim topikal, terapi cahya, utawa obat kaya 5-fluorouracil utawa retinoid. Lesi kasebut dianggep minangka prakanker, kanthi kemungkinan 7. 5 - 10 % dadi karsinoma sel skuamosa utawa sel basal.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Wong lanang umur 52 taun, sadurunge sehat, teka kanthi tembelan sing rata, bentuk cincin ing ujung driji sikil papat, sing wis ana ing kono suwene 2 taun tanpa nyebabake gejala. Diwiwiti minangka benjolan cilik, hard lan tuwuh metu saka wektu. Sanajan nyoba macem-macem perawatan kaya cryotherapy, krim, antijamur, lan antibiotik, tambalan kasebut ora dadi luwih apik. Nliti kanthi rapet karo dermocopsy nuduhake tengah garing, abang kanthi wates sing kandel lan kasar. Sawijining kulit cilik sing dijupuk saka pinggir tembelan nuduhake pertumbuhan sel sing ora normal ing lapisan njaba kulit, konfirmasi diagnosis porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
Asring biopsi ditindakake amarga bisa katon padha karo keratosis aktinik utawa karsinoma sel skuamosa.