Squamous cell carcinoma - Karsinoma Sel Skuamosa
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Squamous cell carcinoma well differentiated ― Keratosis actinic jejer diamati.
References
Squamous cell carcinoma (SCC) minangka kanker kulit paling umum nomer loro ing Amerika Serikat, sawise basal cell carcinoma. Biasane diwiwiti saka lesi prakanker sing diarani actinic keratosis , lan bisa nyebar menyang bagean awak liyane. Penyebab utama yaiku paparan sinar ultraviolet (UV) saka srengenge, sing akumulasi saka wektu. Perawatan biasane nyakup pengangkatan bedhah, utamane kanggo SCC ing sirah lan gulu. Terapi radiasi minangka pilihan kanggo pasien tuwa utawa sing ora bisa operasi. Imunosupresi nambah risiko SCC. Sanajan langka, SCC bisa nyebar, utamane ing pasien sing duwe sistem kekebalan sing kurang. Priksa-up reguler lan pangayoman srengenge penting kanggo sing duwe SCC.
Squamous cell carcinoma of the skin or cutaneous squamous cell carcinoma is the second most common form of skin cancer in the United States, behind basal cell carcinoma. Squamous cell carcinoma has precursor lesions called actinic keratosis, exhibits tumor progression and has the potential to metastasize in the body. Ultraviolet (UV) solar radiation is the primary risk factor in the development of cutaneous squamous cell carcinoma and the cumulative exposure received over a lifetime plays a major part in the development of this cancer. Surgical excision is the primary treatment modality for cutaneous squamous cell carcinoma, with Mohs micrographic surgery being the preferred excisional technique for squamous cell carcinoma of the head and neck, and in other areas of high risk or squamous cell carcinoma with high-risk characteristics. Radiation therapy is reserved for squamous cell carcinoma in older patients or those who will not tolerate surgery, or when it has not been possible to obtain clear margins surgically. Adjuvant radiotherapy is commonly after surgical treatment in very high tumors. Immunosuppression significantly increases the risk of squamous cell carcinoma over the course of an individual’s life. Metastasis is uncommon for squamous cell carcinomas arising in areas of chronic sun exposure, but it can take place, and the risk is increased in immunosuppressed patients. Patients with cutaneous squamous cell carcinoma should be examined regularly and remember to use measures to protect from UV damage.
Squamous cell carcinoma of the skin or cutaneous squamous cell carcinoma is the second most common form of skin cancer in the United States, behind basal cell carcinoma. Squamous cell carcinoma has precursor lesions called actinic keratosis, exhibits tumor progression and has the potential to metastasize in the body. Ultraviolet (UV) solar radiation is the primary risk factor in the development of cutaneous squamous cell carcinoma and the cumulative exposure received over a lifetime plays a major part in the development of this cancer. Surgical excision is the primary treatment modality for cutaneous squamous cell carcinoma, with Mohs micrographic surgery being the preferred excisional technique for squamous cell carcinoma of the head and neck, and in other areas of high risk or squamous cell carcinoma with high-risk characteristics. Radiation therapy is reserved for squamous cell carcinoma in older patients or those who will not tolerate surgery, or when it has not been possible to obtain clear margins surgically. Adjuvant radiotherapy is commonly after surgical treatment in very high tumors. Immunosuppression significantly increases the risk of squamous cell carcinoma over the course of an individual’s life. Metastasis is uncommon for squamous cell carcinomas arising in areas of chronic sun exposure, but it can take place, and the risk is increased in immunosuppressed patients. Patients with cutaneous squamous cell carcinoma should be examined regularly and remember to use measures to protect from UV damage.
Cutaneous squamous cell carcinoma (CSCC) minangka kanker paling umum nomer loro ing wong, lan jumlahe saya mundhak. Sanajan CSCC biasane nuduhake prilaku klinis sing entheng, bisa nyebar sacara lokal lan menyang bagean awak liyane. Para ilmuwan wis nemtokake jalur tartamtu sing melu pangembangan CSCC, sing ndadékaké perawatan anyar. Jumlah mutasi sing dhuwur lan risiko tambah ing pasien immunosuppressed nyebabake pangembangan imunoterapi. Tinjauan iki ndeleng akar genetik CSCC lan perawatan paling anyar sing nargetake molekul tartamtu lan sistem kekebalan.
Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans and its incidence continues to rise. Although CSCC usually display a benign clinical behavior, it can be both locally invasive and metastatic. The signaling pathways involved in CSCC development have given rise to targetable molecules in recent decades. In addition, the high mutational burden and increased risk of CSCC in patients under immunosuppression were part of the rationale for developing the immunotherapy for CSCC that has changed the therapeutic landscape. This review focuses on the molecular basis of CSCC and the current biology-based approaches of targeted therapies and immune checkpoint inhibitors
Cutaneous squamous cell carcinoma (CSCC) is the second most frequent cancer in humans and its incidence continues to rise. Although CSCC usually display a benign clinical behavior, it can be both locally invasive and metastatic. The signaling pathways involved in CSCC development have given rise to targetable molecules in recent decades. In addition, the high mutational burden and increased risk of CSCC in patients under immunosuppression were part of the rationale for developing the immunotherapy for CSCC that has changed the therapeutic landscape. This review focuses on the molecular basis of CSCC and the current biology-based approaches of targeted therapies and immune checkpoint inhibitors
○ Diagnosis lan Perawatan
#Dermoscopy
#Skin biopsy