Syphilis - Sipilis
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Chancres — infeksi sifilis primer sing disebabake dening Treponema pallidum
relevance score : -100.0%
ReferencesSifilis minangka penyakit kelamin sing disebabake dening bakteri Treponema pallidum. Ing panlitèn iki, kita fokus ing 57 pasien umur 18‑68 taun kanthi sifilis sekunder.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
Sifilis minangka infeksi bakteri sing disebabake dening Treponema pallidum. Bisa niru macem‑macem penyakit, lan entuk julukan “great imitator”. Sifilis isih nyerang jutaan wong ing saindenging jagad, nanging bisa diobati kanthi efektif nganggo penisilin.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Treponema pallidum nyebabake sifilis liwat kontak seksual utawa saka ibu marang bayi nalika hamil. Sanajan ana tes sing gampang kanggo diagnosa lan perawatan kanthi siji suntikan penisilin sing dawa lan tumindak kanthi apik, sifilis dadi masalah gedhe maneh ing saindenging jagad. Kondisi iki luwih umum ing antarane wong lanang sing duwe hubungan seksual karo wong lanang (MSM) ing negara berpenghasilan tinggi lan menengah. Sanajan sawetara negara berpendapatan rendah wis nggayuh tujuan WHO kanggo ngilangi sifilis vertikal (ibu menyang bayi), ana peningkatan sifilis ing antarane MSM sing HIV‑positif.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
(1) Enlarged Ati: Iki asring ditemokake lan bisa kedadeyan bebarengan karo limpa sing luwih gedhe. Biopsi ati sing dipriksa nganggo mikroskop darkfield bisa nuduhake anané spirochete. Tes fungsi ati uga bisa ndeteksi kelainan. (2) Kulit Kuning (Jaundice): Kondisi iki muncul gumantung saka tingkat kerusakan ati. (3) Runny Nose: Asring dadi salah siji tandha pisanan, biasane muncul ing minggu pertama sawise lair. (4) Kelenjar Limfa Abuh: Pembengkakan umum kelenjar getah bening, biasane ora krasa lara lan umum ditemokake. (5) Rash Kulit: Ruam biasane katon siji nganti rong minggu sawise irung meler. Sampeyan bisa uga ndeleng bintik abang utawa jambon cilik ing mburi, bokong, pupu, lan tlapak sikil. Ruam iki bisa berkembang dadi peeling lan crusting.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
○ Diagnosis lan Perawatan
VDRL lan RPR bisa digunakake kanggo konfirmasi infeksi anyar lan skrining sifilis. Tes FTA‑ABS minangka tes sing luwih spesifik lan bisa digunakake kanggo mriksa riwayat infeksi sadurunge. Penisilin digunakake kanggo nambani sifilis.