Livedoid vasculitishttps://en.wikipedia.org/wiki/Livedoid_vasculitis
☆ នៅក្នុងលទ្ធផល Stiftung Warentest ឆ្នាំ 2022 ពីប្រទេសអាឡឺម៉ង់ ការពេញចិត្តរបស់អ្នកប្រើប្រាស់ជាមួយ ModelDerm គឺទាបជាងការពិគ្រោះថ្លៃព្យាបាលតាមទូរស័ព្ទបន្តិចប៉ុណ្ណោះ។ វាអាចអមដោយការឈឺចាប់។
relevance score : -100.0%
References Livedoid vasculopathy: A review with focus on terminology and pathogenesis 36285834 NIH
Livedoid vasculopathy គឺជាជំងឺស្បែកដ៏កម្រមួយ ដែលសម្គាល់ដោយដំបៅឈឺចាប់ ដែលបន្តមកលើជើងខាងក្រោម។
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy: A review of pathogenesis and principles of management 27297279Livedoid vasculopathy គឺជាជំងឺស្បែកដ៏កម្រដែលបណ្តាលឱ្យមានដំបៅកើតឡើងដដែលៗនៅលើជើងខាងក្រោម ដែលបន្សល់ទុកនូវស្លាកស្នាមស្លេកដែលគេស្គាល់ថាជា atrophie blanche ។ ខណៈពេលដែលមូលហេតុពិតប្រាកដនៅតែមិនច្បាស់លាស់ វាត្រូវបានគេជឿថាការកើនឡើងនៃកំណកឈាម (hypercoagulability) គឺជាកត្តាចម្បង ដោយការរលាកមានតួនាទីបន្ទាប់បន្សំ។ កត្តាដែលរួមចំណែកដល់ការកកឈាមរួមមានដូចខាងក្រោម - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine ។ ក្នុងការធ្វើកោសល្យវិច័យ ស្ថានភាពបង្ហាញពីកំណកឈាមនៅក្នុងសរសៃឈាម ការឡើងក្រាស់នៃជញ្ជាំងសរសៃឈាម និងស្លាកស្នាម។ ការព្យាបាលពាក់ព័ន្ធនឹងវិធីសាស្រ្តពហុភាគីដែលផ្តោតលើការការពារការកកឈាមជាមួយនឹងថ្នាំដូចជាថ្នាំប្រឆាំងនឹងប្លាកែត ថ្នាំបញ្ចុះឈាម និងការព្យាបាលដោយ fibrinolytic ។ ថ្នាំផ្សេងៗអាចប្រើសម្រាប់ស្ថានភាពស្បែកនេះ - colchicine and hydroxychloroquine, vasodilators, immunosuppressants ។
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid Vasculopathy 32644463 NIH
Livedoid vasculopathy ជាជំងឺកម្រដែលដំបៅកើតលើជើងទាំងសងខាង។ ការបង្កើតកំណកឈាមនៅក្នុងសរសៃឈាមតូចៗ ត្រូវបានគេគិតថា បណ្តាលមកពីការកើនឡើងនៃកំណកឈាម និងការថយចុះនៃកំណកឈាម រួមជាមួយនឹងការខូចខាតដល់ស្រទាប់សរសៃឈាម។ វាច្រើនកើតមានចំពោះស្ត្រី ជាពិសេសអាយុចន្លោះពី 15 ទៅ 50 ឆ្នាំ។ ការឈប់ជក់បារី ការថែរក្សារបួស និងការប្រើប្រាស់ថ្នាំដូចជាថ្នាំបញ្ចុះឈាម និងថ្នាំប្រឆាំងនឹងប្លាកែតមានប្រសិទ្ធភាព។
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.