Drug eruption - 약발진
약발진 (Drug eruption)은 몸 전체에 영향을 미치는 것이 특징입니다.
relevance score : -100.0%
References약물 발진이라고 알려진 약물에 의한 피부 반응은 때때로 심각할 수 있습니다. Severe cutaneous adverse drug reactions (SCARs)이라고 불리는 이러한 심각한 반응은 생명을 위협하는 것으로 간주됩니다. 여기에는 Stevens‑Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), drug reaction with eosinophilia and systemic symptoms (DRESS)과 같은 질환이 포함됩니다. SCARs은 드물지만 입원 환자의 약 2%가 경험합니다.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
31세 여성 환자가 오른쪽 발등에 통증이 없는 붉은 반점을 이유로 피부과를 방문하였다. 그녀는 여드름 흉터에 대한 피코초 레이저 치료 후 전날 doxycycline (100 mg)을 1회 복용했습니다. 지난해 그녀는 레이저 후 같은 용량의 doxycycline 치료를 받은 뒤 같은 부위에서 비슷한 문제를 겪었습니다. 그녀는 특별한 병력이 없으며 국소적으로나 전신적으로 발열과 같은 다른 증상이 없습니다.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
Stevens-Johnson syndrome (SJS) 및 toxic epidermal necrolysis (TEN)은 심각한 피부 반응의 두 형태이며, 다형성 홍반, 포도상구균성 열상 피부 증후군 등 다른 피부 질환 및 약물 반응과는 구별됩니다. SJS/TEN은 피부와 점막에 광범위한 손상을 일으키는 드물고도 심각한 반응으로, 종종 전신 증상을 동반합니다. 원인의 80% 이상이 약물입니다.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
약물발진은 주로 병력 청취와 임상 검사를 통해 진단됩니다. 필요에 따라 피부 생검, 혈액 검사 또는 면역학적 검사가 추가로 유용할 수 있습니다.
발진을 일으키는 일반적인 약물의 예로는 항생제 및 기타 항균제, 설파제, 비스테로이드성 항염증제(NSAID), 악성 종양에 대한 화학요법제, 항경련제 및 향정신성 약물이 있습니다.
○ 진단 및 치료
발열(체온 상승)이 동반될 경우, 가능한 한 빨리 의사의 진료를 받아야 합니다. 의심되는 약물(예: 항생제, 비스테로이드성 항염증제)을 즉시 중단해야 합니다. 병원 방문 전 Cetirizine(세티리진), Loratadine(로라타딘) 등 경구용 항히스타민제를 복용하면 가려움증과 발진 완화에 도움이 될 수 있습니다.
#Cetirizine [Zytec]
#LevoCetirizine [Xyzal]
#Loratadine [Claritin]
혈액검사(CBC, LFT, 호산구수)
의사의 처방에 따른 경구용 스테로이드 및 항히스타민제