Keratoacanthoma - 각질가시세포종
전형적인 각질가시세포종 (Keratoacanthoma)
References
Keratoacanthoma (KA) 은 빠르게 성장하고 저절로 퇴행할 가능성이 있는 것으로 알려진 빈번한 피부 종양입니다. 이는 일반적으로 태양 손상의 병력이 있는 나이가 많고 피부가 흰 남성에게 발생합니다. 절제술이나 모스 현미경 수술을 이용한 수술적 제거가 일반적인 치료법이지만, 다양한 다른 치료법도 있습니다.
Keratoacanthoma (KA) is a common cutaneous tumor characterized by rapid growth and possible spontaneous regression. It most commonly affects older, fair-skinned males with significantly sun damaged skin. Although surgical removal with excision or Mohs micrographic surgery remains the standard of therapy, there are many alternative therapeutic modalities that can be utilized.
Keratoacanthoma (KA) is a common cutaneous tumor characterized by rapid growth and possible spontaneous regression. It most commonly affects older, fair-skinned males with significantly sun damaged skin. Although surgical removal with excision or Mohs micrographic surgery remains the standard of therapy, there are many alternative therapeutic modalities that can be utilized.
Keratoacanthoma (KA) 은 피부의 특정 분비샘에서 시작되는 낮은 등급의 종양으로 현미경으로 보면 squamous cell carcinoma (SCC) 과 유사하게 보입니다. KA가 침습성 SCC의 한 형태로 분류되어야 하는지에 대한 지속적인 논쟁이 있습니다.
Keratoacanthoma (KA) is a comparatively common low-grade tumor that initiates in the pilo-sebaceous glands and pathologically mimics squamous cell carcinoma (SCC). Essentially, strong debates confirm classifying keratoacanthoma as a variant of invasive SCC. The clinical behavior of KA is hardly predictable and the differential diagnosis of keratoacanthoma and other conditions with keratoacanthoma-like pseudocarcinomatous epithelial hyperplasia is challenging, both clinically and histopathologically.
Keratoacanthoma (KA) is a comparatively common low-grade tumor that initiates in the pilo-sebaceous glands and pathologically mimics squamous cell carcinoma (SCC). Essentially, strong debates confirm classifying keratoacanthoma as a variant of invasive SCC. The clinical behavior of KA is hardly predictable and the differential diagnosis of keratoacanthoma and other conditions with keratoacanthoma-like pseudocarcinomatous epithelial hyperplasia is challenging, both clinically and histopathologically.
Cutaneous squamous cell carcinoma (cSCC) 은 특히 노년층에서 두 번째로 흔한 암 유형입니다. 수술은 일반적으로 cSCC를 치료하는 데 사용되지만 수술을 받을 수 없거나 수술을 원하지 않는 일부 환자의 경우 병변 내 치료와 같은 다른 옵션을 고려할 수 있습니다. 전통적인 병변 내 치료법 (methotrexate or 5-fluorouracil) 이 사용되어 왔지만, 병변 내 면역 요법 및 종양 용해 바이러스 요법과 같은 새로운 접근법에 대한 연구가 진행 중입니다. 여기에서는 고전적인 방법부터 최첨단 전략에 이르기까지 cSCC에 대한 다양한 병변 내 치료법을 살펴보겠습니다.
Cutaneous squamous cell carcinoma (cSCC) is the second most frequent cancer in humans, and it is especially common in fragile, elderly people. Surgery is the standard treatment for cSCC but intralesional treatments can be an alternative in those patients who are either not candidates or refuse to undergo surgery. Classic intralesional treatments, including methotrexate or 5-fluorouracil, have been implemented, but there is now a landscape of active research to incorporate intralesional immunotherapy and oncolytic virotherapy into the scene, which might change the way we deal with cSCC in the future. In this review, we focus on intralesional treatments for cSCC (including keratoacanthoma), from classic to very novel strategies.
Cutaneous squamous cell carcinoma (cSCC) is the second most frequent cancer in humans, and it is especially common in fragile, elderly people. Surgery is the standard treatment for cSCC but intralesional treatments can be an alternative in those patients who are either not candidates or refuse to undergo surgery. Classic intralesional treatments, including methotrexate or 5-fluorouracil, have been implemented, but there is now a landscape of active research to incorporate intralesional immunotherapy and oncolytic virotherapy into the scene, which might change the way we deal with cSCC in the future. In this review, we focus on intralesional treatments for cSCC (including keratoacanthoma), from classic to very novel strategies.
현미경으로 보면 각질가시세포종 (keratoacanthoma) 은 편평세포암종과 매우 유사합니다. 일부 병리학자들은 각질가시세포종 (keratoacanthoma) 을 악성 종양이 아닌 별개의 개체로 분류하지만, 임상 및 조직학적 각질가시세포종 (keratoacanthoma) 의 약 6%는 침윤성 및 공격성 편평 세포암으로 진행됩니다.
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#Dermoscopy
#Skin biopsy