Panniculitis - 지방층염
결핵은 중요한 원인 중 하나입니다.
References
Erythema nodosum is the most common form of panniculitis and is characterized by tender erythematous nodules mainly in the lower limbs on the pretibial area. The exact cause of erythema nodosum is unknown, although it appears to be a hypersensitivity response to a variety of antigenic stimuli. Although the etiology is mostly idiopathic, ruling out an underlying disease is imperative before diagnosing primary erythema nodosum. Erythema nodosum can be the first sign of a systemic disease that is triggered by a large group of processes, such as infections, inflammatory diseases, neoplasia, and/or drugs. The most common identifiable causes are streptococcal infections, primary tuberculosis, sarcoidosis, Behçet disease, inflammatory bowel disease, drugs, and pregnancy.
Panniculitis 피하 지방 조직을 포함하는 이질적인 염증성 질환 그룹을 형성합니다. 이러한 장애는 소아에서는 드뭅니다. 지방층염은 전신 장애의 일차적 과정일 수도 있고, 감염, 외상 또는 약물 노출로 인해 발생하는 이차적 과정일 수도 있습니다. 지방층염의 대부분 유형은 압통, 홍반성 피하 결절이 있는 동일한 임상 증상 (병인에 관계없이) 을 나타냅니다.
Panniculitides form a heterogenous group of inflammatory diseases that involve the subcutaneous adipose tissue. These disorders are rare in children and have many aetiologies. As in adults, the panniculitis can be the primary process in a systemic disorder or a secondary process that results from infection, trauma or exposure to medication. Some types of panniculitis are seen more commonly or exclusively in children, and several new entities have been described in recent years. Most types of panniculitis have the same clinical presentation (regardless of the aetiology), with tender, erythematous subcutaneous nodules.
Panniculitides form a heterogenous group of inflammatory diseases that involve the subcutaneous adipose tissue. These disorders are rare in children and have many aetiologies. As in adults, the panniculitis can be the primary process in a systemic disorder or a secondary process that results from infection, trauma or exposure to medication. Some types of panniculitis are seen more commonly or exclusively in children, and several new entities have been described in recent years. Most types of panniculitis have the same clinical presentation (regardless of the aetiology), with tender, erythematous subcutaneous nodules.
Panniculitis , 피하 지방의 염증은 일반적으로 염증성 결절로 나타납니다. Erythema nodosum (EN) 은 임상적으로 가장 흔한 지방층염 형태입니다. EN의 최대 55%는 특발성으로 간주되지만 가장 일반적인 원인에는 감염, 약물, 유육종증 및 염증성 장 질환과 같은 전신 질환, 임신 및 악성 종양이 포함됩니다. EN은 일반적으로 10대와 20대에 나타나며 여성에게 더 흔하게 나타납니다. 종종 발열, 불쾌감, 상부 호흡기 감염 증상을 포함할 수 있는 1~3주 동안의 비특이적 전구증상이 선행됩니다. 그런 다음 피부 병변이 따르며 일반적으로 사지의 신근 측면에 국한됩니다. 병변은 통증이 있는 둥글거나 타원형이며 약간 융기된 비궤양성 붉은 결절입니다. EN의 정확한 발병기전은 알려져 있지 않지만, 피하 지방의 격막 세정맥에 면역 복합체가 침착되어 호중구성 지방층염을 유발하는 것으로 생각됩니다. 원인 질환에 대한 특별한 치료가 없더라도 EN은 대부분의 경우 치료 없이 해결됩니다.
Panniculitis, inflammation of the subcutaneous fat, usually presents with inflammatory nodules. Erythema nodosum (EN) is clinically the most frequent form of panniculitis. Whilst up to 55% of EN is considered idiopathic, the most common causes include infections, drugs, systemic illnesses such as sarcoidosis and inflammatory bowel disease, pregnancy, and malignancy. EN typically presents in the teens and 20s, and is seen more commonly in females. It is often preceded by a non-specific prodrome of one to three weeks, which may include fever, malaise, and symptoms of an upper respiratory tract infection. Cutaneous lesions then follow, typically localized on the extensor aspect of the limbs. The lesions are painful rounded or oval, slightly raised, non-ulcerative red nodules. The exact pathogenesis of EN is not understood, although is thought to result from deposition of immune complexes in the venules of the septae in subcutaneous fat, causing a neutrophilic panniculitis. Even without specific therapy for a causative condition, EN resolves without treatment in most cases.
Panniculitis, inflammation of the subcutaneous fat, usually presents with inflammatory nodules. Erythema nodosum (EN) is clinically the most frequent form of panniculitis. Whilst up to 55% of EN is considered idiopathic, the most common causes include infections, drugs, systemic illnesses such as sarcoidosis and inflammatory bowel disease, pregnancy, and malignancy. EN typically presents in the teens and 20s, and is seen more commonly in females. It is often preceded by a non-specific prodrome of one to three weeks, which may include fever, malaise, and symptoms of an upper respiratory tract infection. Cutaneous lesions then follow, typically localized on the extensor aspect of the limbs. The lesions are painful rounded or oval, slightly raised, non-ulcerative red nodules. The exact pathogenesis of EN is not understood, although is thought to result from deposition of immune complexes in the venules of the septae in subcutaneous fat, causing a neutrophilic panniculitis. Even without specific therapy for a causative condition, EN resolves without treatment in most cases.
"결절홍반"은 발열, 권태감, 관절통 등 전신 증상과 관련된 1~10cm 크기의 부드러운 붉은 결절이 특징인 지방층염 (panniculitis) 의 한 형태입니다. 결절은 궤양이나 흉터 없이 2~6주에 걸쳐 가라앉을 수 있습니다. 결절홍반은 C형 간염, EBV, 결핵, 임신, 비호지킨 림프종, 췌장암 등의 감염과 관련이 있습니다.