Porokeratosis - 한공각화증
가장자리가 딱딱하게 튀어나온 것이 특징입니다.
relevance score : -100.0%
ReferencesPorokeratosis은 각질화 이상을 특징으로 하는 드문 피부 질환으로, 피부에 돌출된 고리 모양의 반점이나 거친 돌기가 나타납니다. 현미경으로 관찰하면 피부 최상층에 특이적인 세포 배열인 각막층이 존재한다는 점이 특징입니다. Porokeratosis은 disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, linear porokeratosis 등 다양한 형태로 나타납니다. Porokeratosis이 잠재적으로 피부암으로 진행될 수 있다는 점에 유의해야 합니다. Porokeratosis를 진단하는 가장 좋은 방법은 융기된 병변의 경계에서 생검을 시행하는 것이지만, 현재 표준 치료 프로토콜은 없습니다.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Disseminated superficial actinic porokeratosis (DSAP)는 무질서한 각질화 질환입니다. 이는 6가지 유형의 다공각화증 중 하나이며, 일반적으로 다른 유형에 비해 더 넓은 부위에 영향을 미칩니다 (linear, Mibelli's, punctate, palmoplantar disseminated, and superficial porokeratosis). 발진성 각화증의 유형은 종종 암, 면역력 약화 또는 염증과 관련이 있습니다. 위험 요인으로는 유전적 요인, 면역 억제, 햇빛 노출 등이 있습니다. DSAP는 햇빛에 노출된 부위에 가장자리가 솟아오른 분홍색 또는 갈색 돌기로 시작되며, 때로는 약간의 가려움증을 유발합니다. 치료법은 다양하며, 국소 크림, 광선 요법 또는 5-fluorouracil(5-플루오로우라실)·retinoid(레티노이드)와 같은 약물이 포함될 수 있습니다. 이러한 병변은 편평 세포 암 또는 기저 세포 암으로 변할 확률이 7.5-10%인 전암성으로 간주됩니다.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
이전에 건강했던 52세 남성이 4번째 발가락 끝에 납작한 고리 모양의 반점이 2년 동안 지속되었으나 별다른 증상 없이 내원하였다. 처음에는 작고 단단한 돌기로 시작했으며 시간이 지남에 따라 바깥쪽으로 확대되었다. 냉동요법, 크림, 항진균제, 항생제 등 다양한 치료를 시도했지만 병변은 호전되지 않았다. 피부경검사 결과, 중앙은 건조하고 붉은색을 띠었으며 테두리는 두껍고 거친 형태였다. 패치 가장자리에서 떼어낸 아주 작은 피부 조각에서 피부 외층에 비정상적인 세포 성장이 관찰되어 porokeratosis of Mibelli 진단이 확정되었다.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
광선각화증이나 편평세포암과 유사하게 보일 수 있어, 종종 생검을 시행합니다.