Prurigo nodularis - 결절성 양진
relevance score : -100.0%
ReferencesPrurigo nodularis은 일반적으로 팔과 다리의 외측에 여러 개의 단단한 돌기와 결절이 나타나는 만성 피부 질환입니다. 이러한 결절은 살색에서 분홍색까지 다양한 색을 띠며, 심한 가려움증을 동반합니다. 모든 연령층에 영향을 줄 수 있으며, 아토피성 피부염과 같이 만성 가려움증을 유발하는 다른 피부 질환과 흔히 동반됩니다. 치료 옵션으로는 강력한 가려움 억제제, 면역 체계에 작용하는 약물, 신경계를 표적으로 하는 약물이 포함됩니다. 결절성 양진을 관리하려면 일반적으로 장기적인 치료가 필요합니다.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
치료에는 일반적으로 영향을 받은 부위에 크림을 바르거나 스테로이드 주사를 하는 것이 포함됩니다. 더 심각하거나 완치가 어려운 경우에는 광선 요법이나 면역 체계를 억제하는 약물 치료가 필요할 수 있습니다. thalidomide(탈리도마이드)와 lenalidomide(레날리도마이드)는 심한 경우에 선택할 수 있지만, 심각한 부작용이 발생할 수 있습니다. 최신 치료법( opioid receptor antagonists, neurokinin‑1 receptor antagonists )은 thalidomide나 lenalidomide에 비해 부작용이 적으며, 결절성 양진을 치료할 가능성이 있음을 보여줍니다.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Chronic prurigo는 장기간 지속되는 가려움증(6주 이상 지속), 긁힘에 의한 피부 병변, 잦은 긁힘 이력이 특징인 피부 질환입니다. 이는 피부의 신경염증과 섬유증을 동반합니다.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Prurigo nodularis은 가려운 결절이 나타나는, 오래 지속되는 피부 문제입니다. 원인은 정확히 밝혀지지 않았지만, 가려움‑스크래치 주기에서 면역 및 신경 문제가 중요한 역할을 하는 것으로 보입니다. 현재 미국 FDA는 결절성 양진증에 대해 특별히 승인한 치료법이 없습니다.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
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병변 부위를 비누로 씻는 것은 전혀 도움이 되지 않으며, 오히려 상태를 악화시킬 수 있습니다. OTC 스테로이드 연고는 증상 완화에 도움이 될 수 있지만, 효과가 나타나려면 일반적으로 몇 주 동안 꾸준히 발라야 합니다. 항히스타민제를 지속적으로 복용하는 것도 가려움증 완화에 도움이 됩니다.
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