Toxic epidermal necrosis - 독성표피괴사 융해증
독성표피괴사 융해증 (Toxic epidermal necrosis)의 특징적인 피부 손실
References
Stevens-Johnson Syndrome (SJS) 및 Toxic Epidermal Necrolysis (TEN) 은 피부가 광범위한 괴사와 탈락을 경험하는 드문 질환입니다. 치료 측면에서 사이클로스포린은 SJS에 매우 효과적이며, 정맥내 면역글로불린 (IVIg) 과 코르티코스테로이드의 병용요법은 SJS 및 TEN의 경우에 가장 효과적입니다.
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin. Regarding treatment, cyclosporine is the most effective therapy for the treatment of SJS, and a combination of intravenous immunoglobulin (IVIg) and corticosteroids is most effective for SJS/TEN overlap and TEN.
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases that are characterized by widespread epidermal necrosis and sloughing of skin. Regarding treatment, cyclosporine is the most effective therapy for the treatment of SJS, and a combination of intravenous immunoglobulin (IVIg) and corticosteroids is most effective for SJS/TEN overlap and TEN.
Toxic epidermal necrolysis (TEN) 은 특정 약물과 면역 체계 활동으로 인해 발생하는 심각한 피부 반응으로, 피부 바깥층 (표피) 이 대규모로 박리되어 신체 표면의 30% 이상에 영향을 미칩니다. TEN의 사망률은 20%가 넘으며, 주로 감염과 호흡 곤란으로 인해 발생합니다. 반응을 유발하는 약물을 중단하고 지지 요법을 제공하며 추가 치료를 사용하면 결과가 개선될 수 있습니다. 최근 연구에 따르면 무작위 대조 시험과 여러 연구 분석을 바탕으로 사이클로스포린, 종양 괴사 인자 알파 억제제, 정맥 내 면역 글로불린과 코르티코스테로이드의 조합과 같은 약물이 도움이 될 수 있는 것으로 나타났습니다.
Toxic epidermal necrolysis (TEN) is a serious skin reaction caused by certain medications and immune system activity, resulting in large-scale detachment of the outer skin layer (epidermis), affecting more than 30% of the body's surface. TEN has a mortality rate of over 20%, often due to infections and breathing difficulties. Stopping the medication causing the reaction, providing supportive care, and using additional treatments can improve the outcome. Recent studies have shown that drugs like cyclosporine, tumor necrosis factor alpha inhibitors, and a combination of intravenous immune globulin and corticosteroids can be helpful, based on randomized controlled trials and analyses of multiple studies.
Toxic epidermal necrolysis (TEN) is a serious skin reaction caused by certain medications and immune system activity, resulting in large-scale detachment of the outer skin layer (epidermis), affecting more than 30% of the body's surface. TEN has a mortality rate of over 20%, often due to infections and breathing difficulties. Stopping the medication causing the reaction, providing supportive care, and using additional treatments can improve the outcome. Recent studies have shown that drugs like cyclosporine, tumor necrosis factor alpha inhibitors, and a combination of intravenous immune globulin and corticosteroids can be helpful, based on randomized controlled trials and analyses of multiple studies.
Recent Advances: There is improved understanding of pain and morbidity with regard to the type and frequency of dressing changes. More modern dressings, such as nanocrystalline, are currently favored as they may be kept in situ for longer periods. The most recent evidence on systemic agents, such as corticosteroids and cyclosporine, and novel treatments, are also discussed.
가장 흔한 원인은 라모트리진, 카르바마제핀, 알로푸리놀, 설폰아미드 항생제, 네비라핀과 같은 특정 약물입니다. 위험 요인으로는 HIV와 전신홍반루푸스가 있습니다. 치료는 일반적으로 화상병동이나 중환자실 등 병원에서 이루어집니다.
○ 치료
이는 심각한 질병이므로 입술이나 입이 영향을 받거나 피부에 물집이 생기면 즉시 의사의 진료를 받으십시오.
의심스러운 약물은 중단해야 합니다. (예: 항생제, 비스테로이드성 항염증제)