Acute generalized exanthematous pustulosis - Pustulosis Exanthematous Giştîkirî Akût
Pustulosis Exanthematous Giştîkirî Akût (Acute generalized exanthematous pustulosis) (AGEP) reaksiyonên çerm ên kêm e ku di 90% bûyeran de bi rêveberiya dermanan ve girêdayî ye. pustulosis exanthematous giştîkirî akût (acute generalized exanthematous pustulosis) bi rijandinên çerm ên nişka ve ku bi navînî pênc rojan piştî destpêkirina dermanek xuya dibin, tê destnîşan kirin. Ev rijandin pustûl in, ango rijandina çerm a sor a piçûk a spî an sor ku tê de maddeya ewr an purul (pişk) heye. Birînên çerm bi gelemperî di nav 1-3 rojan de piştî rawestandina dermanê sûcdar çareser dibin.
☆ Di encamên 2022-an de Stiftung Warentest ji Almanyayê, razîbûna xerîdar bi ModelDerm tenê ji şêwirmendên telemedicine drav hindik hindiktir bû.
Birînên berbelav ên bi erythema û pustules ji nişka ve xuya dibin.
References
Acute generalized exanthematous pustulosis (AGEP) reaksiyonek çerm e ku li ser bingehek çermê sor bi pêlên piçûk, tije pus tê nîşankirin. Ew bi gelemperî dema ku kesek hin dermanan digire, mîna antîbiyotîkan, û zû li laş belav dibe. Piştî rawestandina dermanê destkêşanê, nîşanên bi gelemperî di nav du hefteyan de diçin, bi gelemperî hin rijandina çerm dihêle. Her çend bi gelemperî ne ciddî ne û bi çerm re sînordar be jî, rewşên giran dikarin ligel reaksiyonên çerm ên giran ên wekî Stevens-Johnson syndrome an toxic epidermal necrolysis werin dabeş kirin. Dermankirin di serî de lênihêrîna piştgirî ye, û pêşbîniya ji bo çareseriya tam a nexweşiyê bi gelemperî xweş e.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
Zilamekî 76 salî ji ber ku çermê wî di van du rojên dawî de guherîbû hat odeya lezgîn. Bijîjkan li ser qurm û dest û lingên wî deqên sor û deverên bilindkirî dîtin. Her ku dem derbas dibû, van pêçan li hev diciviyan, û wî di nav deverên sor de qulên mîna pizîkê çêdikirin. Testan jimareya şaneyên xwînê yên spî bi gelek celebek bi navê neutrofîl re, û asta C-reactive protein zêde kirin nîşan dan.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
