Agahiyên bêtir ― Kurdî (kurmancî)

Porokeratosis rewşek çermê ya nadir e ku bi pirsgirêkên keratinîzasyonê ve tê xuyang kirin; di encamê de li ser çerm çîpên bilindkirî, zengilî an girêkên hişk çê dibin. Taybetmendiya wê ya diyarker, ku di binê mikroskopê de hebûna lamellaya kornoîdê nîşan dide, birêkûpêkek taybetî ya hûcreyan di qata jorîn a çerm de ye. Porokeratosis bi awayên cihêreng tê (disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, linear porokeratosis). Girîng e ku were zanîn ku porokeratosis dikare potansiyel bibe kansera çerm. Awayê çêtirîn ji bo tespîtkirina porokeratosis, biopsiya sînorê bilindkirî ye, her çend heya niha protokolek dermankirinê ya standard tune.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.

Disseminated superficial actinic porokeratosis (DSAP) nexweşiya keratinîzasyona nebaş e. Ew yek ji şeş celebên porokeratosis e, û ew bi gelemperî li gorî yên din li deverên mezin bandor dike (linear, Mibelli's, punctate, palmoplantar disseminated, superficial porokeratosis). Cûreya erjeng a porokeratosis bi gelemperî têkildar e bi kanserê, qelsbûna bêparastinê, an iltîhaba. Faktorên xetereyê genetîk, tepisandina parastinê, û rûdana tavê diyar dikin. DSAP li deverên ku ji tavê derdixin de, wek kulpên pembe an qehweyî bi kenavên bilindkirî dest pê dike; carinan dibe sedema xişbûna sivik. Dermankirin cûda dibin û dibe ku kremên herêmî, terapiya ronahiyê, an dermanên mîna 5‑fluorouracil an retinoids bikar bînin. Van birînên pêş‑kanser têne hesibandin, bi 7.5‑10 % şansê veguhertina kansera squamous an kansera bingehîn.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.

Zilamekê 52-salî, ku berê sax bû, di dawiya tiliya çaremîn de bi paçikek zengilî hat hundur, ku 2 sal bû bêyî ku sedema nîşanan bibe. Ew wekî pişkek piçûk dest pê kir, hişk bû û bi demê re li derve mezin bû. Tevî ceribandinên cûrbecûr dermankirinên mîna kryoterapî, krem, antîfungal û antîbiyotik, pêçeka çêtir nebû. Lêkolîna wê bi dermatoskopiyê nêz ve di navenda hişk, sor û bi sînorek qalind û hişk de nîşan da. Parçeyek piçûk a çermê ku ji qiraxa paçê hatî hilanîn, mezinbûna şaneyên nenormal di qata derveyî çerm de nîşan da, ku teşhîsa porokeratosis of Mibelli piştrast dike.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.