Livedoid vasculitis - Livedoid Васкулит
Livedoid Васкулит (Livedoid vasculitis) - негизинен жаш жана орто жаштагы аялдарда байкалган өнөкөт тери оорусу. Анын өзгөчөлүктөрүн сүрөттөө үчүн колдонулган бир аббревиатура: "Төмөнкү учу-кыйырдын ретикулярдык формасы менен ооруган пурпурдук жаралар" (КЫЗГЫЗ КҮЛГҮ). Бул бир катар оорулар менен, анын ичинде өнөкөт веноздук гипертония жана варикоздор менен байланышкан.
☆ Германиянын 2022-жылдагы Stiftung Warentest жыйынтыгында ModelDerm менен керектөөчүлөрдүн канааттануусу телемедициналык акы төлөнүүчү консультацияларга караганда бир аз төмөн болгон.
Бул оору менен коштолушу мүмкүн.
References
Livedoid vasculopathy - сейрек кездешүүчү тери оорусу, ылдыйкы буттарда кайра пайда болгон ооруткан жаралар менен мүнөздөлөт.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy — сейрек кездешүүчү тери оорусу, ал астыңкы буттарда кайталанып жараларды пайда кылып, атрофиялык бланш деп аталган боз тырыктарды калтырат. Так себеби али түшүнүксүз болсо да, кандын уюшунун көбөйүшү (hypercoagulability) негизги фактор болуп саналат, ал эми сезгенүү экинчи ролду ойнойт. Уюган факторлорго төмөнкүлөр кирет - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. Биопсияда абал тамырлардын ичиндеги кандын уюп калышын, тамырлардын дубалдарынын калыңдап кетишин жана тырыктарды көрсөтөт. Дарылоо антитромбоциттер, канды суюлтуучу жана фибринолитикалык терапия сыяктуу дарылар менен кандын уюшун алдын алууга багытталган көп тараптуу мамилени камтыйт. Бул теринин абалына ар кандай дары-дармектер колдонулушу мүмкүн - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy сейрек кездешүүчү абал, анда эки бутунда да жаралар пайда болот. Кичинекей кан тамырларда уюган кандын пайда болушуна кандын уюусунун көбөйүшү жана кандын ыдырашынын азайышы, ошондой эле тамырдын каптамасынын бузулушу себеп болот деп болжолдонууда. Айрыкча 15 жаштан 50 жашка чейинки аялдарда көбүрөөк кездешет. Тамекини таштоо, жарааттарды багуу, канды суюлтуучу жана антиагреганттар сыяктуу дарыларды колдонуу натыйжалуу болду.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
