Dysplastic nevus
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Dysplastic nevi ― Biopsy commendatur pro Occidentalibus.
relevance score : -100.0%
ReferencesDysplastic nevus, quae atypica vel Clarks nevus appellatur, disputationes in dermatologia et dermatopathologia movit. Medici saepe biopsiam huius nevi faciunt, quia potest apparere anomala et suspicionem melanoma excitare.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
Dysplastic nevi, quae atypica vel Clark nevi nota sunt, interdum melanoma ducere possunt. Circa 36 % melanomatum prope nevi dysplasticae inveniuntur. Signa quae nevus dysplasticus in melanoma convertit, figuram inaequalem includunt, mutationes pigmentariae accentuatae vel colorem griseum. Haec carcinomata plerumque in aetate minore (circa triginta annos) fieri possunt et saepe in truncis apparere. Igitur, dysplastic nevi sunt inter nevi benigna et melanoma. Tamen tantum 20 %‑30 % melanomatum ex nevi existentibus oriuntur. Cum plerumque nevi melanoma non fiunt, solet non commendari eas praecavendo removere.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Melanoma est genus tumoris quod melanocytis, cellulis coloris cutis, simile carcinomati fit. Melanocytis a crista neurali originem trahitur. Hoc significat melanomata non solum in cute, sed etiam in aliis locis ubi cellulae neurales a crista migrantes occurrunt, sicut tractus gastrointestinalis et cerebrum. Superstitio pro aegris cum melanoma praematuro (stadium 0) alta est, ad 97 %, dum signanter circa 10 % decrescit pro illis morbis in stadio IV praecognito.
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
○ Periculum cancri
Sicut in populis Caucasicis in Civitatibus Foederatis, qui nevi dysplasticae habent, periculum melanoma super 10 % evolutionis habent. E contra, qui nullum nevo dysplasticae habent, periculum melanoma sub 1 % evolutionis habent.
○ Cautio pro personis cum nevi dysplasticae
Auto‑examinatio cutis plerumque commendatur ad praecavendum melanoma (exprimendo nevi atypicam quae removeri possunt) vel ad detectionem primorum tumorum existentium. Personae cum historia personali vel familiae cancri cutis vel nevi atypici multiplex videre debent dermatologum saltem semel in anno consulere, ut melanoma non praetermittant.
Abbreviatio [ABCDE] utilis est ad auxiliare medicos et laicos meminisse praecipuas notas melanomatis. Infeliciter, persona mediocris, plures keratoses seborrheicae, lentigines senescentes, immo verrucae notabiles possunt haberi, et a melanoma discerni non possunt.
○ [ABCDE]
Asymmetria: vitium cutis asymmetrica.
Bordum: terminus vitii irregularis.
Color: melanomata plerumque varias et irregulares colores habent.
Diameter: nevi maior quam 6 mm magis verisimile melanoma quam nevi minores.
Evolutio: the evolution (i.e. change) of a nevus or lesion may indicate that the lesion is becoming malignant.