Urticaria pigmentosa
Urticaria pigmentosa est forma cutanei mastocytosis frequentissima. Rarus morbus est ex nimia multitudine cellularum mali in cute, quae alvearia vel laesiones in cute irritatae gignunt. Maculae rubrae vel fuscae saepe in cute visae sunt, typice circa pectus, frontem et dorsum. Hae cellulae mali, cum irritatae (exampla cute, expositio caloris attritu), nimium histaminum gignunt, excitat allergicam reactionem quae ducit ad alvearia locata ad locum irritationis, interdum ut "signum Darier".
☆ In anno 2022 Stiftung Warentest ex Germania provenit, satisfactio consumptoria cum ModelDerm paulo minus fuit quam cum consultationibus telemedicinis solutis.
References
Mastocytosis Conditio est ubi cellularum mali excessus est, saepe in variis corporis partibus sicut cutis, medulla ossis et systematis digestivorum invenitur. Secundum Organizationem Mundi Salus (QUI) , cutaneous mastocytosis in tria genera generari potest. Primum genus (mastocytomas) constat solitariis vel paucis (≤3) laesiones. Alterum genus (urticaria pigmentosa) multas laesiones involvit, plerumque a plus quam 10 ad minus quam 100 vagatur. Ultimum genus implicationem per cutem late ostendit. Urticaria pigmentosa Forma communissima est mastocytosis cutanei in haedis, sed etiam in adultis fieri potest. Solet innocens conditio quae in adolescentia saepe melioratur. Mastocytosis adulta dissimilis, raro viscera urticaria pigmentosa afficit. Unius notae notae urticaria pigmentosa proclivitas est ad parvas, scabiosas, rubro-brunneas, vel maculas flavo-brunneas, vel laesiones in cute, vulgo alvos. Hae maculae plerumque in adulescentia apparent et per totam vitam durare possunt.
Mastocytosis is a disorder characterized by mast cell accumulation, commonly in the skin, bone marrow, gastrointestinal (GI) tract, liver, spleen, and lymphatic tissues. The World Health Organization (WHO) divides cutaneous mastocytosis into 3 main presentations. The first has solitary or few (≤3) lesions called mastocytomas. The second, urticaria pigmentosa (UP), involves multiple lesions ranging from >10 to <100 lesions. The last presentation involves diffuse cutaneous involvement. UP is the most common cutaneous mastocytosis in children, but it can form in adults as well. It is considered a benign, self-resolving condition that often remits in adolescence. Unlike adult forms of mastocytosis, there is rarely any internal organ involvement in UP. What makes UP particularly distinctive is its tendency to manifest as small, itchy, reddish-brown, or yellowish-brown spots or lesions on the skin, commonly referred to as urticaria or hives. These spots typically appear in childhood and can persist throughout a person's life.
Mastocytosis is a disorder characterized by mast cell accumulation, commonly in the skin, bone marrow, gastrointestinal (GI) tract, liver, spleen, and lymphatic tissues. The World Health Organization (WHO) divides cutaneous mastocytosis into 3 main presentations. The first has solitary or few (≤3) lesions called mastocytomas. The second, urticaria pigmentosa (UP), involves multiple lesions ranging from >10 to <100 lesions. The last presentation involves diffuse cutaneous involvement. UP is the most common cutaneous mastocytosis in children, but it can form in adults as well. It is considered a benign, self-resolving condition that often remits in adolescence. Unlike adult forms of mastocytosis, there is rarely any internal organ involvement in UP. What makes UP particularly distinctive is its tendency to manifest as small, itchy, reddish-brown, or yellowish-brown spots or lesions on the skin, commonly referred to as urticaria or hives. These spots typically appear in childhood and can persist throughout a person's life.
Puella VI annorum ingressa est cum pluribus maculis atro-coloribus, quae primo in capillo apparuerunt, et deinde ad faciem et corpus per sex menses sparsa sunt. Ea dicta sentiente oriri, rubescere, et psoras cum pressione admota. Non expertus est ruborem, vomitum, alvi fluxionem, non acuendi, et historias medicas personales et domesticas suas exstare non invenit. Quibus inspectis multas maculas obscuras in capite, fronte, facie et collo invenimus, cum aliquantulum elevatis nigricantibus in pectore et retro. Maculae leviter frictiones ut intumescant et pruriant intra 2 minuta, sed indicia defluxerunt intra 15-20 minuta (Darier's sign) .
A 6-year-old female, presented with multiple dark-colored lesions, which started over the scalp and further progressed to involve the face and trunk since past six months. She gave a history of elevation, redness, and itching on the lesions on application of pressure. There was no associated flushing, vomiting, diarrhoea, or wheeze. The personal and family history was not contributory. On examination, there were multiple hyperpigmented macules over the scalp, forehead, face, and neck in addition to minimally elevated hyperpigmented plaques over the chest and the back. Gentle rubbing of the lesions elicited urtication and itching within 2 min and it resolved within 15–20 minutes, suggestive of the Darier's sign.
A 6-year-old female, presented with multiple dark-colored lesions, which started over the scalp and further progressed to involve the face and trunk since past six months. She gave a history of elevation, redness, and itching on the lesions on application of pressure. There was no associated flushing, vomiting, diarrhoea, or wheeze. The personal and family history was not contributory. On examination, there were multiple hyperpigmented macules over the scalp, forehead, face, and neck in addition to minimally elevated hyperpigmented plaques over the chest and the back. Gentle rubbing of the lesions elicited urtication and itching within 2 min and it resolved within 15–20 minutes, suggestive of the Darier's sign.
