Acute generalized exanthematous pustulosis - Akute Generaliséierter Exanthematöser Pustulose
Akute Generaliséierter Exanthematöser Pustulose (Acute generalized exanthematous pustulosis) (AGEP) ass eng selten Hautreaktioun déi an 90% vun de Fäll mat der Medikamenterverwaltung verbonnen ass. akute generaliséierter exanthematöser pustulose (acute generalized exanthematous pustulosis) ass charakteriséiert duerch plötzlech Hautausbréch, déi am Duerchschnëtt fënnef Deeg no der Start vun engem Medikament erscheinen. Dës Ausbréch sinn Pustelen, dh kleng rout wäiss oder rout Eruptioun vun der Haut, déi bewölkt oder purulent Material (Euter) enthalen. D'Hautläsiounen léisen normalerweis bannent 1-3 Deeg no der Stopp vun der beleidegend Medikamenter.
☆ An den 2022 Stiftung Warentest Resultater aus Däitschland war d'Zefriddenheet vum Konsument mam ModelDerm nëmme liicht manner wéi mat bezuelte Telemedizin Konsultatiounen.
Verbreede Läsionen mat Erythem a Pustelen erschéngen op eemol.
References
Acute generalized exanthematous pustulosis (AGEP) ass eng Hautreaktioun markéiert vu klenge, mat Eeter gefëllte Knollen op enger rouder Hautbasis. Et geschitt normalerweis wann een bestëmmte Medikamenter hëlt, wéi Antibiotike, a sech séier iwwer de Kierper verbreet. Nodeems d'Ausléiser Medikamenter gestoppt ginn, ginn d'Symptomer typesch bannent zwou Wochen fort, dacks e bësse Hautausschlag hannerloossen. Och wann normalerweis net eescht a limitéiert ass op d'Haut, kënne schwéiere Fäll zesumme mat anere schlëmmen Hautreaktiounen wéi Stevens-Johnson syndrome oder toxic epidermal necrolysis klassifizéiert ginn. D'Behandlung ass haaptsächlech ënnerstëtzend Betreiung, an d'Prognose fir eng komplett Léisung vun der Krankheet ass normalerweis exzellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
E 76 Joer ale Mann koum op d'Urgence, well seng Haut an de leschten zwee Deeg geännert huet. D'Dokteren hunn rout Flecken an opgehuewe Gebidder op sengem Stamm an Äerm a Been fonnt. Wéi d'Zäit weidergaang ass, hunn dës Flecken sech zesummegefaasst, an hien huet pimple-ähnleche Knollen an de roude Beräicher entwéckelt. Tester weisen héich wäiss Bluttzellzuel mat vill vun enger Aart genannt Neutrophilen, a erhéicht Niveauen vun C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
